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Rabbit polyclonal HIST1H2BG antibody (A9896)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:100 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal HIST1H2BG antibody.
Check alternative names for the antibodyExpand
dJ221C16.8 antibody|H2B histone family, member A antibody|H2B/a antibody|H2B/g antibody|H2B/h antibody|H2B/k antibody|H2B/l antibody|H2B1C_HUMAN antibody|H2BFA antibody|HIST1H2BI antibody|Histone 1, H2bg antibody|Histone cluster 1 H2B family member g antibody|Histone cluster 1, H2bg antibody|Histone H2B type 1-C/E/F/G/I antibody|Histone H2B.1 A antibody|Histone H2B.a antibody|Histone H2B.g antibody|Histone H2B.h antibody|Histone H2B.k antibody|Histone H2B.l antibody|Anti-Histone H2B type 1-C/E/F/G/I (acetyl K12) antibody – ChIP Grade (ab195494)
SCBT cat No:
Rabbit polyclonal HIST1H2BG antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human HIST1H2BG
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 14kDa/Observed: Refer to figures
HIST1H2BG antibody was tube-contained.
HIST1H2BG antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
|Protein sequence and domain|| |
Belongs to the histone H2B family.
|Protein post-translational modifications|| |
Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 ‘Lys-4’ (H3K4me) and ‘Lys-79’ (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ‘Lys-4’ and ‘Lys-79’ methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.; Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.; GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes.; Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
|Protein cellular localization|| |
AntibodyPlus can customize HIST1H2BG antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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