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Rabbit Polyclonal Histone H4 (Acetyl Lys12) antibody (STJ97180)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-2000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
HIST1H4A antibody, H4/A antibody, H4FA; antibody, HIST1H4B antibody, H4/I antibody, H4FI; antibody, HIST1H4C antibody, H4/G antibody, H4FG; antibody, HIST1H4D antibody, H4/B antibody, H4FB; antibody, HIST1H4E antibody, H4/J antibody, H4FJ; antibody, HIST1H4F antibody, H4/C antibody, H4FC; antibody, HIST1H4H antibody, H4/H antibody, H4FH; antibody, HIST1H4I antibody, H4/M antibody, H4FM; antibody, HIST1H4J antibody, H4/E antibody, H4FE; antibody, HIST1H4K antibody, H4/D antibody, H4FD; antibody, HIST1H4L antibody, H4/K antibody, H4FK; antibody, HIST2H4A antibody, H4/N antibody, H4F2 antibody, H4FN antibody, HIST2H4; antibody, HIST2H4B antibody, H4/O antibody, H4FO; antibody, HIST4H4 antibody,|H4_HUMAN antibody|H4F2 antibody|H4FN antibody|HIST1H4 antibody|HIST2H4 antibody|Hist4h4 antibody|HISTH4H4 antibody|Histone H4 antibody|methyl histone H4 antibody|methylated histone H4 antibody|Anti-Histone H4K20me1 Antibody – ChIP Grade (ab9051)
SCBT cat No: To be updated
Histone H4 (Acetyl Lys12) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
The antibody detects endogenous Histone H3 (Acetyl Lys12) protein.
|Recommended dilution|| |
Histone H4 (Acetyl Lys12) Antibody was tube-contained. PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Histone H4 (Acetyl Lys12) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Histone H4 antibody
|Protein names|| |
|Protein function|| |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
|Involvement in disease|| |
Note: Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6.
|Protein sequence and domain|| |
Belongs to the histone H4 family.
|Protein post-translational modifications|| |
Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. / Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation. / Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. / Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. / Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4. / Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me). / Sumoylated, which is associated with transcriptional repression. / Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
|Protein cellular localization|| |
Nucleus / Chromosome
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St John’s Laboratory Ltd.
|Product type|| |
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Antibody customer reviews & validation data - 24
Validation data ID: 24
Submission date: 2016-11-25
Rabbit polyclonal Histone H4 (Acetyle Lys12) antibody
Product catalog No.
St John's Laboratory Ltd
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