Rabbit polyclonal HMGCL antibody (A8052)


Reactivity: Human,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HMGCL antibody (A8052)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


HL antibody
3 hydroxy 3 methylglutaryl CoA lyase antibody|3 hydroxy 3 methylglutaryl Coenzyme A lyase antibody|3 hydroxymethyl 3 methylglutaryl Coenzyme A lyase (hydroxymethylglutaricaciduria) antibody|3 hydroxymethyl 3 methylglutaryl Coenzyme A lyase antibody|3-hydroxy-3-methylglutarate-CoA lyase antibody|HL antibody|HMG CoA lyase antibody|HMG CoA Lyase Deficiency antibody|HMG-CoA lyase antibody|HMGCL antibody|HMGCL_HUMAN antibody|Hydroxymethylglutaricaciduria antibody|Hydroxymethylglutaryl CoA lyase antibody|Hydroxymethylglutaryl CoA lyase mitochondrial antibody|Hydroxymethylglutaryl-CoA lyase antibody|Mitochondrial 3 hydroxy 3 methylglutaryl CoA lyase antibody|mitochondrial antibody|MS725 antibody|OTTHUMP00000044830 antibody|Anti-HMGCL antibody [EPR15550] – N-terminal (ab187648)

SCBT cat No: sc-100548|sc-101973|sc-133661|


Rabbit polyclonal HMGCL antibody

Catalogue No.



Human, Rat


Recombinant protein of human HMGCL





Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200







Molecular weight

Predicted: 34kDa/Observed: Refer to figures


HMGCL antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


HMGCL antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HL antibody

Database links

Human UniProt/Swiss-Prot:P35914

Protein names


Protein function

Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

Protein tissue specificity

Highest expression in liver. Expressed in pancreas, kidney, intestine, testis, fibroblasts and lymphoblasts. Very low expression in brain and skeletal muscle. The relative expression of isoform 2 (at mRNA level) is highest in heart (30%), skeletal muscle (22%), and brain (14%).

Protein sequence and domain

Belongs to the HMG-CoA lyase family.

Protein cellular localization

Mitochondrion matrix. Peroxisome. Note: Unprocessed form is peroxisomal.


The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.


AntibodyPlus can customize HMGCL antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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