Rabbit polyclonal HMGCR antibody (A1633)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal HMGCR antibody (A1633)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:1000 – 1:4000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal HMGCR antibody.

Alternative names:

Check alternative names for the antibody

Expand

LDLCQ3 antibody
3 hydroxy 3 methylglutaryl CoA reductase antibody|3 hydroxy 3 methylglutaryl Coenzyme A reductase antibody|3 hydroxymethylglutaryl CoA reductase antibody|3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody|3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody|3H3M antibody|HMDH_HUMAN antibody|HMG CoA reductase antibody|HMG CoAR antibody|HMG-CoA reductase antibody|Hmgcr antibody|Hydroxymethylglutaryl CoA reductase antibody|LDLCQ3 antibody|MGC103269 antibody|Red antibody|Anti-HMGCR antibody [EPR1685(N)] (ab174830)

SCBT cat No: sc-271595|sc-27578|sc-33827|

Name

Rabbit polyclonal HMGCR antibody

Catalogue No.

A1633

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human HMGCR

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:1000 – 1:4000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 95kDa/Observed: Refer to Figures

Formulation

HMGCR antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HMGCR antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LDLCQ3 antibody

Database links

Human UniProt/Swiss-Prot:P04035

Protein names

LDLCQ3

Protein function

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Protein sequence and domain

Belongs to the HMG-CoA reductase family.; Contains 1 SSD (sterol-sensing) domain.

Protein post-translational modifications

N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.; Undergoes sterol-mediated ubiquitination and ER-association degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1. This INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.

Protein cellular localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Background

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Note

AntibodyPlus can customize HMGCR antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!