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Rabbit polyclonal HMGCR antibody (A1633)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:1000 – 1:4000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
3 hydroxy 3 methylglutaryl CoA reductase antibody|3 hydroxy 3 methylglutaryl Coenzyme A reductase antibody|3 hydroxymethylglutaryl CoA reductase antibody|3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody|3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody|3H3M antibody|HMDH_HUMAN antibody|HMG CoA reductase antibody|HMG CoAR antibody|HMG-CoA reductase antibody|Hmgcr antibody|Hydroxymethylglutaryl CoA reductase antibody|LDLCQ3 antibody|MGC103269 antibody|Red antibody|Anti-HMGCR antibody [EPR1685(N)] (ab174830)
SCBT cat No: sc-271595|sc-27578|sc-33827|
Rabbit polyclonal HMGCR antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human HMGCR
WB, IHC, IF
|Recommended dilution|| |
WB 1:1000 – 1:4000
|Molecular weight|| |
Predicted: 95kDa/Observed: Refer to Figures
HMGCR antibody was tube-contained.
HMGCR antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
|Protein sequence and domain|| |
Belongs to the HMG-CoA reductase family.; Contains 1 SSD (sterol-sensing) domain.
|Protein post-translational modifications|| |
N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.; Undergoes sterol-mediated ubiquitination and ER-association degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1. This INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.
|Protein cellular localization|| |
Endoplasmic reticulum membrane; Multi-pass membrane protein.
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
AntibodyPlus can customize HMGCR antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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