Rabbit polyclonal HNF4A antibody (A2085)


Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HNF4A antibody (A2085)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal HNF4A antibody.

Alternative names:

Check alternative names for the antibody


HNF4A antibody, HNF4 antibody, HNF4a7 antibody, HNF4a8 antibody, HNF4a9 antibody, HNF4alpha antibody, MODY antibody, MODY1 antibody, NR2A1 antibody, NR2A21 antibody, TCF antibody, TCF14 antibody
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SCBT cat No: sc-6556|sc-374229|sc-8987|sc-101059|sc-6557|


Rabbit polyclonal HNF4A antibody

Catalogue No.



Human, Mouse, Rat


A synthetic peptide of human HNF4A





Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200







Molecular weight

Predicted: 52kDa/Observed: Refer to Figures


HNF4A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


HNF4A antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HNF4A antibody, HNF4 antibody, HNF4a7 antibody, HNF4a8 antibody, HNF4a9 antibody, HNF4alpha antibody, MODY antibody, MODY1 antibody, NR2A1 antibody, NR2A21 antibody, TCF antibody, TCF14 antibody

Database links

Human UniProt/Swiss-Prot:P41235

Protein names

HNF4A, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14

Protein function

Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.

Protein sequence and domain

Belongs to the nuclear hormone receptor family. NR2 subfamily.; Contains 1 nuclear receptor DNA-binding domain.

Protein post-translational modifications

Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA.; Acetylation at Lys-458 lowers transcriptional activation by about two-fold.

Protein cellular localization



Hepatocyte nuclear factor 4alpha (HNF4alpha) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver (1). HNF4alpha, in association with PGC-1alpha, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers (2,3). Conditional knockout of the HNF4alpha gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels (4). Mutations in HNF4alpha have been linked to maturity-onset diabetes of the young (MODY) (5).

Research area

All research areas>Transcription Regulators>HNF
(View all antibody categories related to Transcription Regulators)


AntibodyPlus can customize HNF4A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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