Rabbit polyclonal HNRNPA1 antibody (A7491)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HNRNPA1 antibody (A7491)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ALS19 antibody, ALS20 antibody, HNRPA1 antibody, IBMPFD3 antibody, HNRPA1L3 antibody, hnRNP A1 antibody, hnRNP-A1 antibody
HNRNPA 1 antibody|Helix destabilizing protein antibody|Helix-destabilizing protein antibody|Heterogeneous nuclear ribonucleoprotein A1 antibody|Heterogeneous nuclear ribonucleoprotein A1B protein antibody|Heterogeneous nuclear ribonucleoprotein B2 protein antibody|Heterogeneous nuclear ribonucleoprotein core protein A1 antibody|hnRNP A1 antibody|hnRNP core protein A1 antibody|HNRNPA1 antibody|HNRPA1 antibody|MGC102835 antibody|Nuclear ribonucleoprotein particle A1 protein antibody|ROA1_HUMAN antibody|Single strand DNA binding protein UP1 antibody|Single strand RNA binding protein antibody|Single-strand RNA-binding protein antibody|Anti-hnRNP A1 antibody [9H10] (ab5832)

SCBT cat No: sc-32301|sc-56700|sc-166511|sc-374526|sc-10030|sc-365486|sc-10029|sc-10032|

Name

Rabbit polyclonal HNRNPA1 antibody

Catalogue No.

A7491

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human HNRNPA1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 39kDa/Observed: Refer to figures

Formulation

HNRNPA1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HNRNPA1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ALS19 antibody, ALS20 antibody, HNRPA1 antibody, IBMPFD3 antibody, HNRPA1L3 antibody, hnRNP A1 antibody, hnRNP-A1 antibody

Database links

Human UniProt/Swiss-Prot:P09651

Protein names

ALS19, ALS20, HNRPA1, IBMPFD3, HNRPA1L3, hnRNP A1, hnRNP-A1

Protein function

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.

Protein sequence and domain

Contains 2 RRM (RNA recognition motif) domains.

Protein post-translational modifications

Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine.; Sumoylated.

Protein cellular localization

Nucleus. Cytoplasm. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner.

Background

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites.

Research area

All research areas>Transcription Regulators>hnRNP
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize HNRNPA1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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