Rabbit polyclonal HNRNPA2B1 antibody (A1162)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HNRNPA2B1 antibody (A1162)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal HNRNPA2B1 antibody.

Alternative names:

Check alternative names for the antibody

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HNRNPA2B1 antibody,DKFZp779B0244 antibody,FLJ22720 antibody,HNRNPA2 antibody,HNRNPB1 antibody,HNRPA2 antibody,HNRPA2B1 antibody,HNRPB1 antibody,RNPA2 antibody,SNRPB1 antibody
Heterogeneous nuclear ribonucleoprotein A2 antibody|Heterogeneous nuclear ribonucleoprotein A2/B1 antibody|Heterogeneous nuclear ribonucleoprotein B1 antibody|Heterogeneous nuclear ribonucleoproteins A2/B1 antibody|hnRNP A2 / hnRNP B1 antibody|hnRNP A2 antibody|hnRNP A2/B1 antibody|hnRNP B1 antibody|hnRNP-A2 antibody|hnRNP-B1 antibody|hnRNPA2 antibody|Hnrnpa2b1 antibody|hnRNPB1 antibody|HNRPA2 antibody|HNRPA2B1 antibody|HNRPB1 antibody|Nuclear ribonucleoprotein particle A2 protein antibody|RNP A2 antibody|RNP B1 antibody|RNP-A2 antibody|RNP-B1 antibody|RNPA2 antibody|RNPB1 antibody|ROA2_HUMAN antibody|SNRPB1 antibody|Anti-hnRNP A2B1 antibody (ab31645)

SCBT cat No: sc-80993|sc-374053|sc-393726|sc-393674|sc-32316|sc-374052|sc-53531|sc-10035|sc-10036|

Name

Rabbit polyclonal HNRNPA2B1 antibody

Catalogue No.

A1162

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human HNRNPA2B1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 37kDa/Observed: Refer to Figures

Formulation

HNRNPA2B1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HNRNPA2B1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HNRNPA2B1 antibody,DKFZp779B0244 antibody,FLJ22720 antibody,HNRNPA2 antibody,HNRNPB1 antibody,HNRPA2 antibody,HNRPA2B1 antibody,HNRPB1 antibody,RNPA2 antibody,SNRPB1 antibody

Database links

Human UniProt/Swiss-Prot:P22626

Protein names

HNRNPA2B1,DKFZp779B0244,FLJ22720,HNRNPA2,HNRNPB1,HNRPA2,HNRPA2B1,HNRPB1,RNPA2,SNRPB1

Protein function

Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs . Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm . Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear ‘reader’ of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts . Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs . Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs .; (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport.

Protein sequence and domain

The low complexity (LC) region is intrinsically disordered. When incubated at high concentration, it is able to polymerize into labile, amyloid-like fibers and form cross-beta polymerization structures, probably driving the formation of hydrogels. In contrast to irreversible, pathogenic amyloids, the fibers polymerized from LC regions disassemble upon dilution. A number of evidences suggest that formation of cross-beta structures by LC regions mediate the formation of RNA granules, liquid-like droplets, and hydrogels.Contains 2 RRM (RNA recognition motif) domains.

Protein post-translational modifications

Sumoylated in exosomes, promoting miRNAs-binding.; Asymmetric dimethylation at Arg-266 constitutes the major methylation site (By similarity). According to a report, methlytion affects subcellular location and promotes nuclear localization . According to another report, methylation at Arg-266 does not influence nucleocytoplasmic shuttling (By similarity).

Protein cellular localization

Nucleus, nucleoplasm . Cytoplasmic granule . Secreted, exosome . Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs . Component of ribonucleosomes . Not found in the nucleolus . Found in exosomes follwong sumoylation .; Isoform A2: Nucleus . Cytoplasm . Note: Predominantly nucleoplasmic, however is also found in the cytoplasm of cells in some tissues .

Background

Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) is a member of the hnRNP A/B family of related RNA binding proteins that bind pre-mRNA and are involved in the processing, metabolism and transport of nuclear pre-mRNA transcripts (1). Alternative splicing produces transcripts that encode two homologous hnRNP proteins, hnRNPA2 and hnRNPB1, from a single gene sequence (2). Studies demonstrate hnRNP A2/B1 splicing repression across multiple targets (3,4) and that both proteins can bind and protect telomere repeat sequences from DNase digestion (5,6). Altered expression of hnRNP B1 is seen in several forms of cancer, including squamous cell carcinoma, adenocarcinoma, and various forms of lung cancer (7). Over expression of hnRNP B1 may be associated with inhibition of DNA-PK activity and impaired DNA repair during early stages of cancer development (8). Autoantigens to hnRNP A2/B1 (termed RA33) are associated with rheumatoid arthritis, systemic lupus erythromatosus and mixed connective tissue disease (9-11).

Research area

All research areas>Transcription Regulators>hnRNP
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize HNRNPA2B1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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