Rabbit polyclonal HNRNPL antibody (A8430)

$69.00$259.00

Reactivity: Human,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HNRNPL antibody (A8430)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal HNRNPL antibody.

Alternative names:

Check alternative names for the antibody

Expand

HNRPL antibody, hnRNP-L antibody, P/OKcl.14 antibody
D830027H13Rik antibody|FLJ35509 antibody|Heterogeneous nuclear ribonucleoprotein L antibody|hnRNP L antibody|hnRNP-L antibody|Hnrnpl antibody|hnRPL antibody|HNRPL_HUMAN antibody|P/OKcl.14 antibody|Anti-hnRNP L antibody [4D11] (ab6106)

SCBT cat No: sc-32317|sc-46673|sc-48391|sc-393737|sc-28726|

Name

Rabbit polyclonal HNRNPL antibody

Catalogue No.

A8430

Reactivity

Human, Rat

Immunogen

Recombinant protein of human HNRNPL

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 64kDa/Observed: Refer to figures

Formulation

HNRNPL antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HNRNPL antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HNRPL antibody, hnRNP-L antibody, P/OKcl.14 antibody

Database links

Human UniProt/Swiss-Prot:P14866

Protein names

HNRPL, hnRNP-L, P/OKcl.14

Protein function

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements . Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts . Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter .

Protein sequence and domain

RRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre-mRNA .Contains 4 RRM (RNA recognition motif) domains.

Protein post-translational modifications

Several isoelectric forms of the L protein are probably the results of post-translational modifications.; Phosphorylation at Ser-544 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization.

Protein cellular localization

Nucleus, nucleoplasm . Cytoplasm . Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules.

Background

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Transcription Regulators>hnRNP
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize HNRNPL antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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