Rabbit polyclonal HSD17B10 antibody (A5448)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HSD17B10 antibody (A5448)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ABAD antibody, CAMR antibody, ERAB antibody, HCD2 antibody, MHBD antibody, HADH2 antibody, MRPP2 antibody, MRX17 antibody, MRX31 antibody, SCHAD antibody, MRXS10 antibody, SDR5C1 antibody, 17b-HSD10 antibody, DUPXp11.22 antibody
17 beta hydroxysteroid dehydrogenase 10 antibody|17 beta hydroxysteroid dehydrogenase type 10 antibody|17-beta-HSD 10 antibody|17-beta-hydroxysteroid dehydrogenase 10 antibody|17b HSD10 antibody|3 hydroxy 2 methylbutyryl CoA dehydrogenase antibody|3 hydroxyacyl CoA dehydrogenase type 2 antibody|3 hydroxyacyl CoA dehydrogenase type II antibody|3-hydroxy-2-methylbutyryl-CoA dehydrogenase antibody|3-hydroxyacyl-CoA dehydrogenase type II antibody|3-hydroxyacyl-CoA dehydrogenase type-2 antibody|AB binding alcohol dehydrogenase antibody|ABAD antibody|Ads9 antibody|Amyloid beta binding polypeptide antibody|Amyloid beta peptide binding alcohol dehydrogenase antibody|Amyloid beta peptide binding protein antibody|Amyloid beta peptide binding protein antibody|CAMR antibody|DUPXp11.22 antibody|Endoplasmic Reticulum Amyloid Binding Protein antibody|Endoplasmic reticulum associated amyloid beta peptide binding protein antibody|Endoplasmic reticulum-associated amyloid beta-peptide-binding protein antibody|ER associated amyloid beta-binding protein antibody|ERAB antibody|HADH 2 antibody|HADH2 antibody|HCD 2 antibody|HCD2 antibody|HCD2_HUMAN antibody|Hsd17b10 antibody|Hydroxyacyl CoA Dehydrogenase type II antibody|Hydroxyacyl Coenzyme A dehydrogenase type II antibody|Hydroxysteroid (17 beta) dehydrogenase 10 antibody|Mental retardation X linked syndromic 11 antibody|MHBD antibody|Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase antibody|Mitochondrial ribonuclease P protein 2 antibody|Mitochondrial RNase P protein 2 antibody|MRPP2 antibody|MRX17 antibody|SCHAD antibody|SDR5C1 antibody|Short chain dehydrogenase/reductase family 5C member 1 antibody|Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 antibody|Short chain type dehydrogenase/reductase XH98G2 antibody|Short-chain type dehydrogenase/reductase XH98G2 antibody|Type 10 17b HSD antibody|Type 10 17beta hydroxysteroid dehydrogenase antibody|Type II HADH antibody|XH98G2 antibody|Anti-ERAB antibody [EPR11839(B)] (ab167410)

SCBT cat No: sc-136326|sc-7689|sc-393693|sc-393694|sc-292620|

Name

Rabbit polyclonal HSD17B10 antibody

Catalogue No.

A5448

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human HSD17B10

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 27kDa/Observed: Refer to Figures

Formulation

HSD17B10 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HSD17B10 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ABAD antibody, CAMR antibody, ERAB antibody, HCD2 antibody, MHBD antibody, HADH2 antibody, MRPP2 antibody, MRX17 antibody, MRX31 antibody, SCHAD antibody, MRXS10 antibody, SDR5C1 antibody, 17b-HSD10 antibody, DUPXp11.22 antibody

Database links

Human UniProt/Swiss-Prot:Q99714

Protein names

ABAD, CAMR, ERAB, HCD2, MHBD, HADH2, MRPP2, MRX17, MRX31, SCHAD, MRXS10, SDR5C1, 17b-HSD10, DUPXp11.22

Protein function

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5′-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

Protein tissue specificity

Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.

Protein sequence and domain

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein cellular localization

Mitochondrion .

Background

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer’s disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Research area

All research areas>Neurobiology>ERAB
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize HSD17B10 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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