Rabbit polyclonal HSPA1A antibody (A0284)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HSPA1A antibody (A0284)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal HSPA1A antibody.

Alternative names:

Check alternative names for the antibody

Expand

HSP72 antibody, HSPA1 antibody, HSP70I antibody, HSP70-1 antibody, HSP70-1A antibody, HSPA1A antibody
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SCBT cat No:

Name

Rabbit polyclonal HSPA1A antibody

Catalogue No.

A0284

Reactivity

Human, Mouse

Immunogen

A synthetic peptide of human HSPA1A

Host

Rabbit

Applications

WB, IF

Recommended dilution

WB 1:500 – 1:2000
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 70kDa/Observed: Refer to Figures

Formulation

HSPA1A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HSPA1A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HSP72 antibody, HSPA1 antibody, HSP70I antibody, HSP70-1 antibody, HSP70-1A antibody, HSPA1A antibody

Database links

Human UniProt/Swiss-Prot:P08107

Protein names

HSP72, HSPA1, HSP70I, HSP70-1, HSP70-1A, HSPA1A

Protein function

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation .

Protein sequence and domain

Belongs to the heat shock protein 70 family.

Protein cellular localization

Cytoplasm . Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Background

HSPA1A and HSP90 are molecular chaperones expressed constitutively under normal conditions to maintain protein homeostasis and are induced upon environmental stress (1). Both HSPA1A and HSP90 are able to interact with unfolded proteins to prevent irreversible aggregation and catalyze the refolding of their substrates in an ATP- and co-chaperone-dependent manner (1). HSPA1A has a broad range of substrates including newly synthesized and denatured proteins, while HSP90 tends to have a more limited subset of substrates, most of which are signaling molecules. HSPA1A and HSP90 often function collaboratively in a multi-chaperone system, which requires a minimal set of co-chaperones: HSP40, Hop, and p23 (2,3). The co-chaperones either regulate the intrinsic ATPase activity of the chaperones or recruit chaperones to specific substrates or subcellular compartments (1,4). When the ubiquitin ligase CHIP associates with the HSPA1A/HSP90 complex as a cofactor, the unfolded substrates are subjected to degradation by the proteasome (4). The biological functions of HSPA1A/HSP90 extend beyond their chaperone activity. They are essential for the maturation and inactivation of nuclear hormones and other signaling molecules (1,3). They also play a role in vesicle formation and protein trafficking (2).

Research area

All research areas>Signaling Intermediates>Glucose-Regulated Protein
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize HSPA1A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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