Rabbit polyclonal HSPA5 antibody (A0241)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HSPA5 antibody (A0241)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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HSPA5 antibody,BIP antibody,FLJ26106 antibody,GRP78 antibody,MIF2 antibody
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SCBT cat No: sc-13539|sc-376768|sc-1051|sc-13968|

Name

Rabbit polyclonal HSPA5 antibody

Catalogue No.

A0241

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human HSPA5

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 78kDa/Observed: Refer to Figures

Formulation

HSPA5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HSPA5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HSPA5 antibody,BIP antibody,FLJ26106 antibody,GRP78 antibody,MIF2 antibody

Database links

Human UniProt/Swiss-Prot:P11021

Protein names

HSPA5,BIP,FLJ26106,GRP78,MIF2

Protein function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Protein sequence and domain

Belongs to the heat shock protein 70 family.

Protein cellular localization

Endoplasmic reticulum lumen. Melanosome. Cytoplasm . Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Background

Secretory and transmembrane proteins are synthesized on polysomes and translocated into the endoplasmic reticulum (ER). Inside the ER, these proteins are often modified by disulfide bond formation, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including HSPA5. HSPA5 was identified as an immunoglobulin heavy chain binding protein in pre-B cells (1,2). It was also found to be induced at the protein level by glucose starvation (3). When protein folding is disturbed inside ER, HSPA5 synthesis is increased. Subsequently, HSPA5 binds to misfolded proteins to prevent them from forming aggregates and assists in proper refolding (4).

Research area

All research areas>Signaling Intermediates>Glucose-Regulated Protein
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize HSPA5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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