Rabbit polyclonal HSPA8 antibody (A2487)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HSPA8 antibody (A2487)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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LAP1 antibody, HSC54 antibody, HSC70 antibody, HSC71 antibody, HSP71 antibody, HSP73 antibody, NIP71 antibody, HSPA10 antibody
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SCBT cat No: sc-59560|sc-71270|sc-7298|sc-1059|sc-514369|

Name

Rabbit polyclonal HSPA8 antibody

Catalogue No.

A2487

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human HSPA8

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 70kDa/Observed: Refer to Figures

Formulation

HSPA8 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HSPA8 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LAP1 antibody, HSC54 antibody, HSC70 antibody, HSC71 antibody, HSP71 antibody, HSP73 antibody, NIP71 antibody, HSPA10 antibody

Database links

Human UniProt/Swiss-Prot:P11142

Protein names

LAP1, HSC54, HSC70, HSC71, HSP71, HSP73, NIP71, HSPA10

Protein function

Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The N-terminal 1-386 residues constitute the ATPase domain, while residues 387-646 form the peptide-binding domain.Belongs to the heat shock protein 70 family.

Protein post-translational modifications

Acetylated.; ISGylated.; Trimethylation at Lys-561 reduces fibrillar SNCA binding.

Protein cellular localization

Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.

Background

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Signaling Intermediates>HSC
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize HSPA8 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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