Rabbit polyclonal HTRA2 antibody (A5762)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HTRA2 antibody (A5762)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal HTRA2 antibody.

Alternative names:

Check alternative names for the antibody

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OMI antibody, PARK13 antibody, PRSS25 antibody
High temperature requirement protein A2 antibody|HTRA 2 antibody|HtrA like serine protease antibody|HtrA serine peptidase 2 antibody|HtrA, E. coli, homolog of, 2 antibody|HtrA2 antibody|HTRA2_HUMAN antibody|mitochondrial antibody|Omi stress regulated endoprotease antibody|Omi stress-regulated endoprotease antibody|PARK 13 antibody|PARK13 antibody|Protease serine 25 antibody|PRSS 25 antibody|PRSS25 antibody|Serine protease 25 antibody|Serine protease HTRA2 antibody|Serine protease HTRA2 mitochondrial antibody|Serine protease htra2 mitochondrial precursor antibody|Serine protease omi antibody|Serine proteinase OMI antibody|Anti-HtrA2 / Omi antibody [E55] (ab32092)

SCBT cat No: sc-58371|sc-271528|sc-365594|sc-25606|sc-15467|

Name

Rabbit polyclonal HTRA2 antibody

Catalogue No.

A5762

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human HTRA2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 48kDa/Observed: Refer to Figures

Formulation

HTRA2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HTRA2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

OMI antibody, PARK13 antibody, PRSS25 antibody

Database links

Human UniProt/Swiss-Prot:O43464

Protein names

OMI, PARK13, PRSS25

Protein function

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

Protein tissue specificity

Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.

Protein sequence and domain

The mature N-terminus is involved in the interaction with XIAP.; The PDZ domain mediates interaction with MXI2.Belongs to the peptidase S1C family.; Contains 1 PDZ (DHR) domain.

Protein post-translational modifications

Autoproteolytically activated.

Protein cellular localization

Mitochondrion intermembrane space. Mitochondrion membrane ; Single-pass membrane protein . Note: Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.

Background

This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.

Research area

All research areas>Synthesis and Degradation>Htr
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize HTRA2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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