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Rabbit polyclonal HUS1 antibody (A5407)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal HUS1 antibody.
Check alternative names for the antibodyExpand
Checkpoint protein HUS1 antibody|hHUS1 antibody|HUS1 (S. pombe) checkpoint homolog antibody|Hus1 antibody|HUS1 checkpoint homolog (S. pombe) antibody|HUS1 Checkpoint Protein antibody|HUS1 protein antibody|HUS1+ – like protein antibody|HUS1_HUMAN antibody|Hydroxyurea-sensitive 1, S. pombe, homolog of antibody|Anti-HUS1 antibody (ab186850)
SCBT cat No: sc-30543|sc-166440|sc-8323|sc-30542|
Rabbit polyclonal HUS1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human HUS1
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 31kDa/Observed: Refer to Figures
HUS1 antibody was tube-contained.
HUS1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3′-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the HUS1 family.
|Protein cellular localization|| |
Nucleus . Cytoplasm, cytosol . Note: In discrete nuclear foci upon DNA damage. According to PubMed:11077446, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm.
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
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|Product type|| |
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