Rabbit polyclonal IDH1 antibody (A2169)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,CHIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IDH1 antibody (A2169)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,CHIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:50 – 1:200 ChIP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal IDH1 antibody.

Alternative names:

Check alternative names for the antibody

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IDCD antibody, IDH antibody, IDP antibody, IDPC antibody, PICD antibody
Cytosolic NADP isocitrate dehydrogenase antibody|Cytosolic NADP-isocitrate dehydrogenase antibody|Epididymis luminal protein 216 antibody|Epididymis secretory protein Li 26 antibody|HEL-216 antibody|HEL-S-26 antibody|ICDH antibody|IDCD antibody|IDH antibody|IDH1 antibody|IDHC_HUMAN antibody|IDP antibody|IDPC antibody|Isocitrate dehydrogenase [NADP] cytoplasmic antibody|Isocitrate dehydrogenase 1 (NADP+) soluble antibody|NADP dependent isocitrate dehydrogenase cytosolic antibody|NADP dependent isocitrate dehydrogenase peroxisomal antibody|NADP(+)-specific ICDH antibody|Oxalosuccinate decarboxylase antibody|PICD antibody|Anti-Isocitrate dehydrogenase antibody [EPR12296] (ab172964)

SCBT cat No: sc-515396|sc-49996|sc-373816|sc-55668|sc-374476|

Name

Rabbit polyclonal IDH1 antibody

Catalogue No.

A2169

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human IDH1

Host

Rabbit

Applications

WB, IHC, IF, IP, CHIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:50 – 1:200
ChIP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 47kDa/Observed: Refer to Figures

Formulation

IDH1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IDH1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IDCD antibody, IDH antibody, IDP antibody, IDPC antibody, PICD antibody

Database links

Human UniProt/Swiss-Prot:O75874

Protein names

IDCD, IDH, IDP, IDPC, PICD

Protein sequence and domain

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Protein post-translational modifications

Acetylation at Lys-374 dramatically reduces catalytic activity.

Protein cellular localization

Cytoplasm . Peroxisome .

Background

IDH1 is one of three isocitrate dehydrogenases that catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG). These enzymes exist in two distinct subclasses that utilize either NAD or NADP+ respectively, as an electron acceptor (1). IDH1 is the NADP+-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. IDH2 and 3 are mitochodrial enzymes that also function in the Krebs cycle. IDH1 is inactivated by phosphorylation at Ser113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock (2,3). IDH1 is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma (4). IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway (5).

Research area

All research areas>Synthesis and Degradation>IDH
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize IDH1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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