Rabbit polyclonal IFIT3 antibody (A3924)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IFIT3 antibody (A3924)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:1000 IHC 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

P60 antibody, IRG2 antibody, IFI60 antibody, IFIT4 antibody, ISG60 antibody, RIG-G antibody, cig41 antibody, CIG-49 antibody, GARG-49 antibody
CIG 49 antibody|CIG49 antibody|GARG 49 antibody|IFI-60K antibody|IFI60 antibody|IFI60K antibody|IFIT-3 antibody|IFIT-4 antibody|Ifit3 antibody|IFIT3_HUMAN antibody|IFIT4 antibody|Interferon induced 60 kDa protein antibody|Interferon induced protein 60 antibody|Interferon induced protein with tetratricopeptide repeats 3 antibody|Interferon-induced 60 kDa protein antibody|Interferon-induced protein with tetratricopeptide repeats 3 antibody|Interferon-induced protein with tetratricopeptide repeats 4 antibody|IRG2 antibody|ISG-60 antibody|ISG60 antibody|P60 antibody|Retinoic acid induced gene G protein antibody|Retinoic acid-induced gene G protein antibody|RIG G antibody|RIG-G antibody|RIGG antibody|RP11-149I23.4 antibody|Anti-IFIT3 antibody (ab76818)

SCBT cat No: sc-393512|sc-82950|sc-393396|sc-133687|sc-82954|

Name

Rabbit polyclonal IFIT3 antibody

Catalogue No.

A3924

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human IFIT3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:1000
IHC 1:100 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 56kDa/Observed: Refer to figures

Formulation

IFIT3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IFIT3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

P60 antibody, IRG2 antibody, IFI60 antibody, IFIT4 antibody, ISG60 antibody, RIG-G antibody, cig41 antibody, CIG-49 antibody, GARG-49 antibody

Database links

Human UniProt/Swiss-Prot:O14879

Protein names

P60, IRG2, IFI60, IFIT4, ISG60, RIG-G, cig41, CIG-49, GARG-49

Protein function

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

Protein tissue specificity

Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver.

Protein sequence and domain

Belongs to the IFIT family.; Contains 8 TPR repeats.

Protein cellular localization

Cytoplasm. Mitochondrion.

Research area

All research areas>Signaling Intermediates>IFIT
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize IFIT3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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