Rabbit polyclonal IGF2BP2 antibody (A2749)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IGF2BP2 antibody (A2749)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:200 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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IMP2 antibody, IMP-2 antibody, VICKZ2 antibody
Hepatocellular carcinoma autoantigen p62 antibody|IF2B2_HUMAN antibody|IGF 2 mRNA binding protein 2 antibody|IGF II mRNA binding protein 2 antibody|IGF-II mRNA-binding protein 2 antibody|IGF2 mRNA-binding protein 2 antibody|Igf2bp2 antibody|IMP 2 antibody|IMP-2 antibody|IMP2 antibody|Insulin like growth factor 2 mRNA binding protein 2 antibody|Insulin-like growth factor 2 mRNA-binding protein 2 antibody|OTTHUMP00000082606 antibody|OTTHUMP00000082607 antibody|OTTHUMP00000082608 antibody|p62 antibody|VICKZ 2 antibody|VICKZ family member 2 antibody|VICKZ2 antibody|Anti-IGF2BP2 antibody [EPR6741(B)] (ab124930)

SCBT cat No: sc-377014|sc-292208|sc-99463|sc-99464|

Name

Rabbit polyclonal IGF2BP2 antibody

Catalogue No.

A2749

Reactivity

Human, Mouse

Immunogen

A synthetic peptide of human IGF2BP2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:200 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 66kDa/Observed: Refer to Figures

Formulation

IGF2BP2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IGF2BP2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IMP2 antibody, IMP-2 antibody, VICKZ2 antibody

Database links

Human UniProt/Swiss-Prot:Q9Y6M1

Protein names

IMP2, IMP-2, VICKZ2

Protein function

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript ‘caging’ into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5′-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.

Protein tissue specificity

Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.

Protein sequence and domain

Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules.Belongs to the RRM IMP/VICKZ family.; Contains 4 KH domains.; Contains 2 RRM (RNA recognition motif) domains.

Protein cellular localization

Nucleus. Cytoplasm. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Background

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5′ UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms.

Research area

All research areas>Growth Factors and Hormones>IGF2BP
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize IGF2BP2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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