Rabbit polyclonal IGF2BP3 antibody (A2750)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IGF2BP3 antibody (A2750)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

KOC antibody, CT98 antibody, IMP3 antibody, KOC1 antibody, IMP-3 antibody, VICKZ3 antibody
Cancer/testis antigen 98 antibody|CT98 antibody|DKFZp686F1078 antibody|hKOC antibody|IF2B3_HUMAN antibody|IGF II mRNA binding protein 3 antibody|IGF-II mRNA-binding protein 3 antibody|IGF2 mRNA binding protein 3 antibody|IGF2 mRNA-binding protein 3 antibody|IGF2BP3 antibody|IMP 3 antibody|IMP-3 antibody|Insulin like growth factor 2 mRNA binding protein 3 antibody|Insulin-like growth factor 2 mRNA-binding protein 3 antibody|KH domain containing protein overexpressed in cancer antibody|KH domain-containing protein overexpressed in cancer antibody|KOC 1 antibody|KOC1 antibody|VICKZ 3 antibody|VICKZ family member 3 antibody|VICKZ3 antibody|Anti-IMP3 antibody [EPR12021] (ab177477)

SCBT cat No: sc-365641|sc-390639|sc-100766|sc-365640|sc-366419|sc-376067|sc-292451|

Name

Rabbit polyclonal IGF2BP3 antibody

Catalogue No.

A2750

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human IGF2BP3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 64kDa/Observed: Refer to Figures

Formulation

IGF2BP3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IGF2BP3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

KOC antibody, CT98 antibody, IMP3 antibody, KOC1 antibody, IMP-3 antibody, VICKZ3 antibody

Database links

Human UniProt/Swiss-Prot:O00425

Protein names

KOC, CT98, IMP3, KOC1, IMP-3, VICKZ3

Protein function

RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript ‘caging’ into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3′-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5′-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.

Protein tissue specificity

Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.

Protein sequence and domain

All KH domains contribute binding to target mRNA. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules.Belongs to the RRM IMP/VICKZ family.; Contains 4 KH domains.; Contains 2 RRM (RNA recognition motif) domains.

Protein cellular localization

Nucleus. Cytoplasm. Note: Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Background

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5′ UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.

Note

AntibodyPlus can customize IGF2BP3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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