Rabbit polyclonal IHH antibody (A6626)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IHH antibody (A6626)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

BDA1 antibody, HHG2 antibody
BDA1 antibody|HHG-2 antibody|HHG2 antibody|IHH antibody|IHH_HUMAN antibody|Indian Hedgehog antibody|Indian hedgehog homolog antibody|Indian hedgehog protein antibody|Indian hedgehog protein C-product antibody|Indian hedgehog protein N-product antibody|Anti-Ihh antibody (ab39634)

SCBT cat No: sc-1196|sc-271101|sc-13088|sc-1782|

Name

Rabbit polyclonal IHH antibody

Catalogue No.

A6626

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human IHH

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to figures

Formulation

IHH antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IHH antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BDA1 antibody, HHG2 antibody

Database links

Human UniProt/Swiss-Prot:Q14623

Protein names

BDA1, HHG2

Protein function

Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).

Protein tissue specificity

Expressed in embryonic lung, and in adult kidney and liver.

Protein sequence and domain

The indian hedgehog protein N-product binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain.Belongs to the hedgehog family.

Protein post-translational modifications

The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity (By similarity).; Cholesterylation is required for N-product targeting to lipid rafts and multimerization.; Palmitoylated. N-palmitoylation is required for N-product multimerization and full activity.

Protein cellular localization

Indian hedgehog protein N-product: Cell membrane ; Lipid-anchor ; Extracellular side . Note: The N-terminal peptide remains associated with the cell surface.; Indian hedgehog protein C-product: Secreted, extracellular space . Note: The C-terminal peptide diffuses from the cell.; Cell membrane .

Background

This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.

Research area

All research areas>Growth Factors and Hormones>Ihh
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize IHH antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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