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Rabbit polyclonal IHH antibody (A6626)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal IHH antibody.
Check alternative names for the antibodyExpand
BDA1 antibody, HHG2 antibody
BDA1 antibody|HHG-2 antibody|HHG2 antibody|IHH antibody|IHH_HUMAN antibody|Indian Hedgehog antibody|Indian hedgehog homolog antibody|Indian hedgehog protein antibody|Indian hedgehog protein C-product antibody|Indian hedgehog protein N-product antibody|Anti-Ihh antibody (ab39634)
SCBT cat No: sc-1196|sc-271101|sc-13088|sc-1782|
Rabbit polyclonal IHH antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human IHH
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 45kDa/Observed: Refer to figures
IHH antibody was tube-contained.
IHH antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
BDA1 antibody, HHG2 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).
|Protein tissue specificity|| |
Expressed in embryonic lung, and in adult kidney and liver.
|Protein sequence and domain|| |
The indian hedgehog protein N-product binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain.Belongs to the hedgehog family.
|Protein post-translational modifications|| |
The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity (By similarity).; Cholesterylation is required for N-product targeting to lipid rafts and multimerization.; Palmitoylated. N-palmitoylation is required for N-product multimerization and full activity.
|Protein cellular localization|| |
Indian hedgehog protein N-product: Cell membrane ; Lipid-anchor ; Extracellular side . Note: The N-terminal peptide remains associated with the cell surface.; Indian hedgehog protein C-product: Secreted, extracellular space . Note: The C-terminal peptide diffuses from the cell.; Cell membrane .
This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.
AntibodyPlus can customize IHH antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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