Rabbit polyclonal IKZF3 antibody (A7287)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IKZF3 antibody (A7287)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal IKZF3 antibody.

Alternative names:

Check alternative names for the antibody

Expand

AIO antibody, AIOLOS antibody, ZNFN1A3 antibody
AIO antibody|Aiolos antibody|IKAROS family zinc finger 3 (Aiolos) antibody|IKAROS family zinc finger 3 antibody|Ikaros family zinc finger protein 3 antibody|IKZF 3 antibody|IKZF3 antibody|IKZF3_HUMAN antibody|zinc finger DNA binding protein Aiolos antibody|Zinc finger protein Aiolos antibody|Zinc finger protein subfamily 1A 3 (Aiolos) antibody|Zinc finger protein subfamily 1A 3 antibody|Zinc finger protein subfamily 1A, member 3 antibody|ZNFN1A3 antibody|Anti-IKZF3 antibody [EPR9342(B)] (ab139408)

SCBT cat No: sc-101982|sc-160013|

Name

Rabbit polyclonal IKZF3 antibody

Catalogue No.

A7287

Reactivity

Human

Immunogen

Recombinant protein of human IKZF3

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 58kDa/Observed: Refer to figures

Formulation

IKZF3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IKZF3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

AIO antibody, AIOLOS antibody, ZNFN1A3 antibody

Database links

Human UniProt/Swiss-Prot:Q9UKT9

Protein names

AIO, AIOLOS, ZNFN1A3

Protein function

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.

Protein tissue specificity

Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.

Protein sequence and domain

Belongs to the Ikaros C2H2-type zinc-finger protein family.; Contains 6 C2H2-type zinc fingers.

Protein post-translational modifications

Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.

Protein cellular localization

Nucleus. Cytoplasm.

Background

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.

Research area

All research areas>Transcription Regulators>Aiolos
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize IKZF3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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