Rabbit polyclonal IL11RA antibody (A6627)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IL11RA antibody (A6627)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CRSDA antibody
CRSDA antibody|hCG_2011440 antibody|I11RA_HUMAN antibody|IL-11 receptor subunit alpha antibody|IL-11R subunit alpha antibody|IL-11R-alpha antibody|IL-11RA antibody|IL11RA antibody|Interleukin 11 receptor alpha antibody|Interleukin 11 receptor alpha chain antibody|Interleukin-11 receptor subunit alpha antibody|MGC2146 antibody|Anti-IL11RA antibody [EPR5446] (ab125015)

SCBT cat No: sc-130920|sc-31419|sc-393057|sc-992|sc-393039|

Name

Rabbit polyclonal IL11RA antibody

Catalogue No.

A6627

Reactivity

Human

Immunogen

Recombinant protein of human IL11RA

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to figures

Formulation

IL11RA antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IL11RA antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CRSDA antibody

Database links

Human UniProt/Swiss-Prot:Q14626

Protein names

CRSDA

Protein function

Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.

Protein tissue specificity

Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma.

Protein sequence and domain

Belongs to the type I cytokine receptor family. Type 3 subfamily.; Contains 2 fibronectin type-III domains.; Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Protein cellular localization

Membrane; Single-pass type I membrane protein.

Background

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene.

Research area

All research areas>Membrane Receptors>IL-11R
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize IL11RA antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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