Rabbit polyclonal IL16 antibody (A1764)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IL16 antibody (A1764)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal IL16 antibody.

Alternative names:

Check alternative names for the antibody

Expand

LCF antibody, NIL16 antibody, PRIL16 antibody, prIL-16 antibody
HGNC:5980 antibody|HsT19289 antibody|IL-16 antibody|IL16 antibody|IL16_HUMAN antibody|Interleukin 16 precursor antibody|Interleukin-16 antibody|LCF antibody|Lymphocyte chemoattractant factor antibody|Neuronal interleukin 16 antibody|NIL16 antibody|prIL 16 antibody|PrIL16 antibody|Prointerleukin 16 antibody|Anti-IL16 antibody [EPR19988] (ab207181)

SCBT cat No: sc-374606|sc-374604|sc-1941|sc-374605|sc-7902|

Name

Rabbit polyclonal IL16 antibody

Catalogue No.

A1764

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human IL16

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 142kDa/Observed: Refer to Figures

Formulation

IL16 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IL16 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LCF antibody, NIL16 antibody, PRIL16 antibody, prIL-16 antibody

Database links

Human UniProt/Swiss-Prot:Q14005

Protein names

LCF, NIL16, PRIL16, prIL-16

Protein function

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.; Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Protein tissue specificity

Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation.

Protein sequence and domain

Contains 4 PDZ (DHR) domains.

Protein post-translational modifications

Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.

Protein cellular localization

Interleukin-16: Secreted.; Isoform 1: Cytoplasm .; Isoform 3: Cytoplasm. Nucleus.

Background

The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants.

Research area

All research areas>Growth Factors and Hormones>IL-16
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize IL16 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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