Rabbit polyclonal IL1A antibody (A2170)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IL1A antibody (A2170)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

IL-1A antibody, IL1 antibody, IL1-ALPHA antibody, IL1F1 antibody
BAF antibody|BAF_HUMAN antibody|BANF 1 antibody|BANF1 antibody|Barrier to autointegration factor 1 antibody|Barrier to autointegration factor antibody|Barrier-to-autointegration factor antibody|BCRG 1 antibody|BCRG1 antibody|BCRP 1 antibody|BCRP1 antibody|Breakpoint cluster region protein 1 antibody|D14S1460 antibody|MGC111161 antibody|NGPS antibody|Anti-IL1 alpha antibody (ab7632)

SCBT cat No: sc-1253|sc-271618|sc-7929|

Name

Rabbit polyclonal IL1A antibody

Catalogue No.

A2170

Reactivity

Human

Immunogen

Recombinant protein of human IL1A

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 31kDa/Observed: Refer to Figures

Formulation

IL1A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IL1A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IL-1A antibody, IL1 antibody, IL1-ALPHA antibody, IL1F1 antibody

Database links

Human UniProt/Swiss-Prot:P01583

Protein names

IL-1A, IL1, IL1-ALPHA, IL1F1

Protein function

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Protein sequence and domain

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.Belongs to the IL-1 family.

Protein cellular localization

Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Background

IL-1alpha is a pro-inflammatory cytokine produced by activated monocytes, lymphocytes and epithelial cells (1). IL-1alpha is synthesized as an active precursor protein that appears to be cleaved by cytosolic proteases into its mature form (1,2). Often, precursor and mature forms of IL-1alpha are primarily retained intracellularly rather than constitutively secreted. (1,2). Signaling by IL-1alpha involves IL-1alpha binding to an IL-1 accessory protein (IL-1-AcP) and then the complex binds to IL-1RI (1,2). Signaling is through activation of MAP kinase and NFkappaB pathways (1,2). IL-1alpha also binds to an IL-RII that lacks an intracellular signaling domain and thereby serves as a high affinity decoy receptor. Inhibition of IL-1alpha activity is through IL-1R antagonist (IL-1Ra) that binds IL-1R1 but does not signal. IL-1alpha has been shown to be a key mediator of virus-induced inflammatory responses in mice (3).

Note

AntibodyPlus can customize IL1A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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