Rabbit polyclonal IL1RN antibody (A2088)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IL1RN antibody (A2088)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

ICIL-1RA antibody, IL-1ra3 antibody, IL1F3 antibody, IL1RA antibody, IRAP antibody, MGC10430 antibody
DIRA antibody|F630041P17Rik antibody|ICIL 1RA antibody|ICIL-1RA antibody|ICIL1RA antibody|IL-1ra antibody|IL-1ra3 antibody|IL-1RN antibody|IL1 inhibitor antibody|IL1F3 antibody|IL1RA antibody|IL1RA_HUMAN antibody|IL1RN (IL1F3) antibody|IL1RN antibody|Interleukin 1 receptor antagonist antibody|Interleukin-1 receptor antagonist protein antibody|Intracellular IL 1 receptor antagonist type II antibody|Intracellular interleukin 1 receptor antagonist (icIL 1ra) antibody|IRAP antibody|MGC10430 antibody|MVCD4 antibody|Type II interleukin 1 receptor antagonist antibody|Anti-IL1RA antibody [EPR6483] (ab124962)

SCBT cat No: sc-8482|sc-8481|

Name

Rabbit polyclonal IL1RN antibody

Catalogue No.

A2088

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human IL1RN

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 20kDa/Observed: Refer to Figures

Formulation

IL1RN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IL1RN antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ICIL-1RA antibody, IL-1ra3 antibody, IL1F3 antibody, IL1RA antibody, IRAP antibody, MGC10430 antibody

Database links

Human UniProt/Swiss-Prot:P18510

Protein names

ICIL-1RA, IL-1ra3, IL1F3, IL1RA, IRAP, MGC10430

Protein function

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Protein tissue specificity

The intracellular form of IL1RN is predominantly expressed in epithelial cells.

Protein cellular localization

Isoform 1: Secreted.; Isoform 2: Cytoplasm.; Isoform 3: Cytoplasm.; Isoform 4: Cytoplasm.

Background

The founding members of the interleukin-1 (IL-1) superfamily include pro-inflammatory cytokines IL-1alpha and IL-1beta, and a third protein that acts as an IL-1 receptor antagonist (IL-1RA). At least six similar proteins have been recently identified, including a homolog of IL-1RA (IL1F5). The three better-characterized proteins (IL-1a, IL-1b and IL-1RA) are mainly expressed in macrophages, monocytes, and dendritic cells. IL-1a and IL-1b act as potent inflammatory cytokines that help regulate host defense and immune responses (1). Binding of these pro-inflammatory cytokines to an IL-1 receptor recruits adapter proteins (such as IRAK) to the receptor. Phosphorylation of these adaptor proteins promotes downstream signaling cascades associated with the immune response (2). Altered expression of both IL-1a and IL-1b is associated with an extensive list of human disorders, including Alzheimer’s disease, rheumatoid arthritis, psoriasis and various forms of cancer (3,4). IL-1RA acts as an anti-inflammatory cytokine, binding the IL-1 receptor to limit the response to inflammation (5). Because it plays a key role in regulating the inflammatory response, recombinant IL-1RA is a therapeutic agent used in the treatment of diseases such as rheumatoid arthritis. Alternatively, mutation of the corresponding IL-1RA gene may be associated with susceptibility to the development of specific cancers (6).

Note

AntibodyPlus can customize IL1RN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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