Rabbit polyclonal IL1RN antibody (A2088)


Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IL1RN antibody (A2088)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


ICIL-1RA antibody, IL-1ra3 antibody, IL1F3 antibody, IL1RA antibody, IRAP antibody, MGC10430 antibody
DIRA antibody|F630041P17Rik antibody|ICIL 1RA antibody|ICIL-1RA antibody|ICIL1RA antibody|IL-1ra antibody|IL-1ra3 antibody|IL-1RN antibody|IL1 inhibitor antibody|IL1F3 antibody|IL1RA antibody|IL1RA_HUMAN antibody|IL1RN (IL1F3) antibody|IL1RN antibody|Interleukin 1 receptor antagonist antibody|Interleukin-1 receptor antagonist protein antibody|Intracellular IL 1 receptor antagonist type II antibody|Intracellular interleukin 1 receptor antagonist (icIL 1ra) antibody|IRAP antibody|MGC10430 antibody|MVCD4 antibody|Type II interleukin 1 receptor antagonist antibody|Anti-IL1RA antibody [EPR6483] (ab124962)

SCBT cat No: sc-8482|sc-8481|


Rabbit polyclonal IL1RN antibody

Catalogue No.



Human, Mouse, Rat


Recombinant protein of human IL1RN





Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200







Molecular weight

Predicted: 20kDa/Observed: Refer to Figures


IL1RN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


IL1RN antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ICIL-1RA antibody, IL-1ra3 antibody, IL1F3 antibody, IL1RA antibody, IRAP antibody, MGC10430 antibody

Database links

Human UniProt/Swiss-Prot:P18510

Protein names

ICIL-1RA, IL-1ra3, IL1F3, IL1RA, IRAP, MGC10430

Protein function

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Protein tissue specificity

The intracellular form of IL1RN is predominantly expressed in epithelial cells.

Protein cellular localization

Isoform 1: Secreted.; Isoform 2: Cytoplasm.; Isoform 3: Cytoplasm.; Isoform 4: Cytoplasm.


The founding members of the interleukin-1 (IL-1) superfamily include pro-inflammatory cytokines IL-1alpha and IL-1beta, and a third protein that acts as an IL-1 receptor antagonist (IL-1RA). At least six similar proteins have been recently identified, including a homolog of IL-1RA (IL1F5). The three better-characterized proteins (IL-1a, IL-1b and IL-1RA) are mainly expressed in macrophages, monocytes, and dendritic cells. IL-1a and IL-1b act as potent inflammatory cytokines that help regulate host defense and immune responses (1). Binding of these pro-inflammatory cytokines to an IL-1 receptor recruits adapter proteins (such as IRAK) to the receptor. Phosphorylation of these adaptor proteins promotes downstream signaling cascades associated with the immune response (2). Altered expression of both IL-1a and IL-1b is associated with an extensive list of human disorders, including Alzheimer’s disease, rheumatoid arthritis, psoriasis and various forms of cancer (3,4). IL-1RA acts as an anti-inflammatory cytokine, binding the IL-1 receptor to limit the response to inflammation (5). Because it plays a key role in regulating the inflammatory response, recombinant IL-1RA is a therapeutic agent used in the treatment of diseases such as rheumatoid arthritis. Alternatively, mutation of the corresponding IL-1RA gene may be associated with susceptibility to the development of specific cancers (6).


AntibodyPlus can customize IL1RN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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