Rabbit polyclonal IL21R antibody (A7468)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IL21R antibody (A7468)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal IL21R antibody.

Alternative names:

Check alternative names for the antibody

Expand

NILR antibody, CD360 antibody
CD360 antibody|IL 21R antibody|IL-21 receptor antibody|IL-21R antibody|IL21 receptor antibody|IL21R antibody|IL21R_HUMAN antibody|Interleukin 21 receptor antibody|Interleukin-21 receptor antibody|MGC10967 antibody|NILR antibody|Novel interleukin receptor antibody|Anti-IL21 Receptor antibody (ab13268)

SCBT cat No: sc-515062|sc-137120|sc-32902|sc-23075|

Name

Rabbit polyclonal IL21R antibody

Catalogue No.

A7468

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human IL21R

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 59kDa/Observed: Refer to figures

Formulation

IL21R antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IL21R antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NILR antibody, CD360 antibody

Database links

Human UniProt/Swiss-Prot:Q9HBE5

Protein names

NILR, CD360

Protein function

This is a receptor for interleukin-21.

Protein tissue specificity

Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.

Protein sequence and domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; The box 1 motif is required for JAK interaction and/or activation.Belongs to the type I cytokine receptor family. Type 4 subfamily.; Contains 2 fibronectin type-III domains.

Protein post-translational modifications

C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.

Protein cellular localization

Membrane; Single-pass type I membrane protein.

Background

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Note

AntibodyPlus can customize IL21R antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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