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Rabbit polyclonal IL21R antibody (A7468)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal IL21R antibody.
Check alternative names for the antibodyExpand
NILR antibody, CD360 antibody
CD360 antibody|IL 21R antibody|IL-21 receptor antibody|IL-21R antibody|IL21 receptor antibody|IL21R antibody|IL21R_HUMAN antibody|Interleukin 21 receptor antibody|Interleukin-21 receptor antibody|MGC10967 antibody|NILR antibody|Novel interleukin receptor antibody|Anti-IL21 Receptor antibody (ab13268)
SCBT cat No: sc-515062|sc-137120|sc-32902|sc-23075|
Rabbit polyclonal IL21R antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human IL21R
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 59kDa/Observed: Refer to figures
IL21R antibody was tube-contained.
IL21R antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
NILR antibody, CD360 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
This is a receptor for interleukin-21.
|Protein tissue specificity|| |
Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
|Protein sequence and domain|| |
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; The box 1 motif is required for JAK interaction and/or activation.Belongs to the type I cytokine receptor family. Type 4 subfamily.; Contains 2 fibronectin type-III domains.
|Protein post-translational modifications|| |
C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.
|Protein cellular localization|| |
Membrane; Single-pass type I membrane protein.
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
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|Product type|| |
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