Rabbit polyclonal IL31RA antibody (A6141)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IL31RA antibody (A6141)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CRL antibody, GPL antibody, CRL3 antibody, GLMR antibody, GLM-R antibody, PLCA2 antibody, hGLM-R antibody, IL-31RA antibody, PRO21384 antibody
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SCBT cat No:

Name

Rabbit polyclonal IL31RA antibody

Catalogue No.

A6141

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human IL31RA

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 82kDa/Observed: Refer to Figures

Formulation

IL31RA antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IL31RA antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CRL antibody, GPL antibody, CRL3 antibody, GLMR antibody, GLM-R antibody, PLCA2 antibody, hGLM-R antibody, IL-31RA antibody, PRO21384 antibody

Database links

Human UniProt/Swiss-Prot:Q8NI17

Protein names

CRL, GPL, CRL3, GLMR, GLM-R, PLCA2, hGLM-R, IL-31RA, PRO21384

Protein function

Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 . May function in skin immunity . Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).

Protein tissue specificity

Expressed in CD14- and CD56-positive blood cells . Expressed in macrophages . Expressed in keratinocytes . Expressed in a subset of dorsal root ganglia neurons (at protein level) . Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin . Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts . Detected in all of the myelomonocytic lineage . Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients .

Protein sequence and domain

Belongs to the type I cytokine receptor family. Type 2 subfamily.; Contains 5 fibronectin type-III domains.

Protein post-translational modifications

N-glycosylated.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse, presynaptic cell membrane . Cell projection, axon .

Background

The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Research area

All research areas>Membrane Receptors>IL-31R
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize IL31RA antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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