Rabbit polyclonal IL36A antibody (A8207)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IL36A antibody (A8207)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal IL36A antibody.

Alternative names:

Check alternative names for the antibody

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FIL1 antibody, FIL1E antibody, IL1F6 antibody, IL-1F6 antibody, IL1(EPSILON) antibody, FIL1(EPSILON) antibody
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SCBT cat No:

Name

Rabbit polyclonal IL36A antibody

Catalogue No.

A8207

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human IL36A

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 18kDa/Observed: Refer to figures

Formulation

IL36A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IL36A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FIL1 antibody, FIL1E antibody, IL1F6 antibody, IL-1F6 antibody, IL1(EPSILON) antibody, FIL1(EPSILON) antibody

Database links

Human UniProt/Swiss-Prot:Q9UHA7

Protein names

FIL1, FIL1E, IL1F6, IL-1F6, IL1(EPSILON), FIL1(EPSILON)

Protein function

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.

Protein tissue specificity

Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin.

Protein sequence and domain

Belongs to the IL-1 family.

Protein post-translational modifications

N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).

Protein cellular localization

Secreted .

Research area

All research areas>Membrane Receptors>IL-1F
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize IL36A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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