Rabbit polyclonal IL6R antibody (A1570)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IL6R antibody (A1570)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal IL6R antibody.

Alternative names:

Check alternative names for the antibody

Expand

CD126 antibody,IL6R-1 antibody,IL6R-alpha antibody,IL6RA antibody,MGC104991 antibody
CD 126 antibody|CD126 antibody|CD126 antigen antibody|gp80 antibody|IL 6R 1 antibody|IL 6R alpha antibody|IL 6R antibody|IL-6 receptor alpha chain antibody|IL-6 receptor subunit alpha antibody|IL-6R 1 antibody|IL-6R subunit alpha antibody|IL-6R-alpha antibody|IL-6RA antibody|IL6Q antibody|Il6r antibody|IL6RA antibody|IL6RA_HUMAN antibody|IL6RQ antibody|Interleukin 6 receptor antibody|interleukin 6 receptor, alpha antibody|Interleukin-6 receptor subunit alpha antibody|Membrane glycoprotein 80 antibody|MGC30256 antibody|Anti-IL6R antibody [B-R6] (ab47215)

SCBT cat No: sc-71366|sc-65328|sc-661|sc-374259|sc-13947|

Name

Rabbit polyclonal IL6R antibody

Catalogue No.

A1570

Reactivity

Human

Immunogen

Recombinant protein of human IL6R

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to Figures

Formulation

IL6R antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IL6R antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD126 antibody,IL6R-1 antibody,IL6R-alpha antibody,IL6RA antibody,MGC104991 antibody

Database links

Human UniProt/Swiss-Prot:P08887

Protein names

CD126,IL6R-1,IL6R-alpha,IL6RA,MGC104991

Protein function

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.; Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

Protein tissue specificity

Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.

Protein sequence and domain

The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.; The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.Belongs to the type I cytokine receptor family. Type 3 subfamily.; Contains 2 fibronectin type-III domains.; Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Protein post-translational modifications

A short soluble form may also be released from the membrane by proteolysis.

Protein cellular localization

Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.

Background

Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL6R, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL6R, the complex of IL-6 and IL6R associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL6R is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892). Soluble form of IL6R has been found in human serum and urine.

Note

AntibodyPlus can customize IL6R antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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