Rabbit polyclonal ILK antibody (A0901)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ILK antibody (A0901)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:1000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ILK antibody,DKFZp686F1765 antibody,P59 antibody,ILK1 antibody
59 kDa serine/threonine protein kinase antibody|59 kDa serine/threonine-protein kinase antibody|DKFZp686F1765 antibody|Epididymis secretory protein Li 28 antibody|HEL S 28 antibody|ILK 1 antibody|ILK 2 antibody|ILK antibody|ILK-1 antibody|ILK-2 antibody|ILK_HUMAN antibody|ILK1 antibody|ILK2 antibody|Integrin linked kinase 2 antibody|Integrin linked Kinase antibody|Integrin linked protein kinase antibody|Integrin-linked protein kinase antibody|p59 antibody|p59ILK antibody|Anti-Integrin linked ILK antibody [EP1593Y] (ab52480)

SCBT cat No: sc-20019|sc-7516|sc-137221|sc-13075|

Name

Rabbit polyclonal ILK antibody

Catalogue No.

A0901

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ILK

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:1000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 59kDa/Observed: Refer to Figures

Formulation

ILK antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ILK antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ILK antibody,DKFZp686F1765 antibody,P59 antibody,ILK1 antibody

Database links

Human UniProt/Swiss-Prot:Q13418

Protein names

ILK,DKFZp686F1765,P59,ILK1

Protein function

Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Protein tissue specificity

Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

Protein sequence and domain

A PH-like domain is involved in phosphatidylinositol phosphate binding.Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.; Contains 5 ANK repeats.; Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated on serine residues.

Protein cellular localization

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium . Cytoplasm, myofibril, sarcomere.

Background

Integrin-linked kinases (ILKs) couple integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility (1). ILK functions as a scaffold bridging the extracellular matrix (ECM) and growth factor receptors to the actin cytoskeleton through interactions with integrin, PINCH (which links ILK to the RTKs via Nck2), CH-ILKBP and affixin (1). ILK phosphorylates Akt at Ser473, GSK-3 on Ser9, myosin light chain 2 (MLC2) on Ser18/Thr19, as well as affixin (2-5). These phosphorylation events are key regulatory steps in modulating the activities of the targets. ILK activity is stimulated by PI3 kinase and negatively regulated by the tumor suppressor PTEN and a PP2C protein phosphatase, ILKAP (1,3,6). It has been suggested that the conserved Ser343 residue in the activation loop plays a key role in the activation of ILK1 (2).

Research area

All research areas>Kinases and Phosphatases>ILK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize ILK antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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