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Rabbit polyclonal IMPA1 antibody (A6381)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal IMPA1 antibody.
Check alternative names for the antibodyExpand
IMP antibody, IMPA antibody
IMP 1 antibody|IMP antibody|IMPA 1 antibody|IMPA antibody|IMPA1 antibody|IMPA1_HUMAN antibody|IMPase 1 antibody|IMPase antibody|Inositol 1(or 4) monophosphatase antibody|Inositol monophosphatase 1 antibody|Inositol monophosphatase antibody|Inositol(myo) 1(or 4) monophosphatase 1 antibody|Inositol-1(or 4)-monophosphatase 1 antibody|Lithium sensitive myo inositol monophosphatase A1 antibody|Lithium-sensitive myo-inositol monophosphatase A1 antibody|Anti-IMPA1 antibody [EPR15404(B)] (ab184165)
SCBT cat No: sc-373733|sc-374234|sc-50596|
Rabbit polyclonal IMPA1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human IMPA1
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 30kDa/Observed: Refer to Figures
IMPA1 antibody was tube-contained.
IMPA1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
IMP antibody, IMPA antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2′-AMP as substrates.
|Protein sequence and domain|| |
Belongs to the inositol monophosphatase family.
|Protein cellular localization|| |
This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2′-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
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|Product type|| |
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