Rabbit polyclonal IMPA1 antibody (A6381)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IMPA1 antibody (A6381)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal IMPA1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

IMP antibody, IMPA antibody
IMP 1 antibody|IMP antibody|IMPA 1 antibody|IMPA antibody|IMPA1 antibody|IMPA1_HUMAN antibody|IMPase 1 antibody|IMPase antibody|Inositol 1(or 4) monophosphatase antibody|Inositol monophosphatase 1 antibody|Inositol monophosphatase antibody|Inositol(myo) 1(or 4) monophosphatase 1 antibody|Inositol-1(or 4)-monophosphatase 1 antibody|Lithium sensitive myo inositol monophosphatase A1 antibody|Lithium-sensitive myo-inositol monophosphatase A1 antibody|Anti-IMPA1 antibody [EPR15404(B)] (ab184165)

SCBT cat No: sc-373733|sc-374234|sc-50596|

Name

Rabbit polyclonal IMPA1 antibody

Catalogue No.

A6381

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human IMPA1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 30kDa/Observed: Refer to Figures

Formulation

IMPA1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IMPA1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IMP antibody, IMPA antibody

Database links

Human UniProt/Swiss-Prot:P29218

Protein names

IMP, IMPA

Protein function

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2′-AMP as substrates.

Protein sequence and domain

Belongs to the inositol monophosphatase family.

Protein cellular localization

Cytoplasm .

Background

This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2′-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Note

AntibodyPlus can customize IMPA1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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