Rabbit polyclonal INADL antibody (A8476)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal INADL antibody (A8476)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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Cipp antibody, PATJ antibody, hINADL antibody, InaD-like antibody
Channel interacting PDZ domain protein antibody|Cipp antibody|FLJ26982 antibody|hINADL antibody|Inactivation no after potential D like protein antibody|INAD like antibody|InaD like Drosophila antibody|INAD like protein antibody|INADL antibody|INADL protein antibody|PALS 1 associated tight junction protein antibody|PALS1 associated tight junction protein antibody|PATJ antibody|PDZ domain protein antibody|PDZ domain protein Drosophila inaD like antibody|Post synaptic density 95 / discs large / zonula occludens 1 domain protein antibody|Protein associated to tight junctions antibody|Anti-PATJ antibody (ab134784)

SCBT cat No: sc-23242|

Name

Rabbit polyclonal INADL antibody

Catalogue No.

A8476

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human INADL

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 196kDa/Observed: Refer to figures

Formulation

INADL antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

INADL antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

Cipp antibody, PATJ antibody, hINADL antibody, InaD-like antibody

Database links

Human UniProt/Swiss-Prot:Q8NI35

Protein names

Cipp, PATJ, hINADL, InaD-like

Protein function

Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries .

Protein tissue specificity

Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain.

Protein sequence and domain

The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5 localization to tight junctions.; The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization.Contains 1 L27 domain.; Contains 10 PDZ (DHR) domains.

Protein cellular localization

Cell junction, tight junction . Apical cell membrane ; Peripheral membrane protein . Cytoplasm, perinuclear region . Cell membrane ; Peripheral membrane protein . Note: Localized in the paranodal region of myelinating Schwann cells (By similarity). Membrane-associated. Localizes to tight junctions in epithelial cells . Also found at the apical plasma membrane.

Background

This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.

Note

AntibodyPlus can customize INADL antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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