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Rabbit polyclonal INCENP antibody (A0622)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal INCENP antibody.
Check alternative names for the antibodyExpand
binds and activates aurora B and C in vivo and in vitro antibody|Chromosomal passenger protein antibody|INCE_HUMAN antibody|INCENP antibody|Inner centromere protein antibody|Inner centromere protein antigens 135/155kDa antibody|Inner centromere protein antigens 135kD 155kD antibody|Inner centromere protein INCENP antibody|Anti-INCENP antibody (ab12183)
SCBT cat No: sc-376514|sc-47894|sc-47895|
Rabbit polyclonal INCENP antibody
|Catalogue No.|| |
Recombinant protein of human INCENP
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 140kDa/Observed: Refer to Figures
INCENP antibody was tube-contained.
INCENP antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1.
|Protein sequence and domain|| |
Belongs to the INCENP family.
|Protein post-translational modifications|| |
Phosphorylation by AURKB at its C-terminal part is important for AURKB activation by INCENP.
|Protein cellular localization|| |
Nucleus . Chromosome, centromere . Cytoplasm, cytoskeleton, spindle . Midbody . Chromosome, centromere, kinetochore . Note: Colocalized at synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocenters. Colocalizes with AURKB at a connecting strand traversing the centromere region and joining sister kinetochores, in metaphase II centromeres. This strand disappears at the metaphase II/anaphase II transition and relocalizes to the spindle midzone (By similarity). Colocalizes with AURKB at mitotic chromosomes . Localizes to inner kinetochore . Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis . Cocalizes to the equatorial cell cortex at anaphase .
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and ‘passenger,’ or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term ‘passenger proteins’ encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis
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|Product type|| |
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