Rabbit polyclonal ING3 antibody (A5832)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ING3 antibody (A5832)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ING3 antibody.

Alternative names:

Check alternative names for the antibody

Expand

Eaf4 antibody, ING2 antibody, MEAF4 antibody, p47ING3 antibody
1300013A07Rik antibody|Eaf 4 antibody|Eaf4 antibody|FLJ20089 antibody|ING 2 antibody|ING 3 antibody|ING2 antibody|Inhibitor of growth family member 3 antibody|Inhibitor of growth protein 3 antibody|MEAF4 antibody|p47 ING 3 antibody|p47 ING3 antibody|p47 regulator protein antibody|p47ING3 antibody|p47ING3 protein antibody|Anti-ING3 antibody (ab115470)

SCBT cat No: sc-101245|

Name

Rabbit polyclonal ING3 antibody

Catalogue No.

A5832

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ING3

Host

Rabbit

Applications

WB, IHC, IF, IP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 46kDa/Observed: Refer to Figures

Formulation

ING3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ING3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

Eaf4 antibody, ING2 antibody, MEAF4 antibody, p47ING3 antibody

Database links

Human UniProt/Swiss-Prot:Q9NXR8

Protein names

Eaf4, ING2, MEAF4, p47ING3

Protein function

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome – DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Protein tissue specificity

Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.

Protein sequence and domain

The PHD-type zinc finger mediates the binding to H3K4me3.Belongs to the ING family.; Contains 1 PHD-type zinc finger.

Protein cellular localization

Nucleus.

Background

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.

Research area

All research areas>Tumor Suppressor/Apoptosis>ING
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize ING3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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