Rabbit Polyclonal Integrin beta3 antibody (STJ97287)

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Reactivity: Human
Applications: WB, IHC, IF
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Integrin beta3 antibody (STJ97287)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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ITGB3 antibody, GP3A antibody,|BDPLT16 antibody|BDPLT2 antibody|CD 61 antibody|CD61 antibody|CD61 antigen antibody|GP3A antibody|GPIIIa antibody|GT antibody|HPA 1 antibody|HPA 4 antibody|Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody|Integrin beta chain beta 3 antibody|Integrin beta-3 antibody|ITB3_HUMAN antibody|ITG B3 antibody|ITGB 3 antibody|ITGB3 antibody|NAIT antibody|Platelet fibrinogen receptor beta subunit antibody|Platelet fibrinogen receptor, beta subunit antibody|Platelet glycoprotein IIIa antibody|Platelet glycoprotein IIIa precursor antibody|Platelet membrane glycoprotein IIIa antibody|PTP antibody|Anti-Integrin beta 3 antibody [EPR2342] (ab119992)
SCBT cat No: sc-7312|sc-52684|sc-81632|sc-13588|sc-59970|sc-59971|sc-71453|sc-71454|sc-71455|sc-1185|sc-71456|sc-46676|sc-19989|sc-19618|sc-6619|sc-398708|sc-26692|sc-398725|

Name

Integrin beta3 Polyclonal Antibody

Catalogue No.

STJ97287

Reactivity

Human

Specificity

Integrin beta3 Polyclonal Antibody detects endogenous levels of Integrin beta3 protein.

Immunogen

Synthesized peptide derived from Integrin beta-3 at AA range 621-670

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Formulation

Integrin beta3 Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Integrin beta3 Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Integrin beta-3 antibody, Platelet membrane glycoprotein IIIa antibody, GPIIIa antibody, CD antigen CD61 antibody

Database links

Human UniProt/Swiss-Prot:P05106;Mouse UniPort/Swiss-Prot: O54890;Rat UniProt/Swiss-Port: Q8R2H2;Human Entrez Gene: 3690;Mouse Entrez Gene: 16416;Rat Entrez Gene: Rn.229225

Protein names

Integrin beta-3 , Platelet membrane glycoprotein IIIa , GPIIIa , CD antigen CD61

Protein function

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). / (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 . Integrin ITGAV:ITGB3 acts as a receptor for coxsackievirus A9 . Acts as a receptor for Hantaan virus . Integrin ITGAV:ITGB3 acts as a receptor for cytomegalovirus/HHV-5 . Integrin ITGA5:ITGB3 acts as a receptor for human metapneumovirus . Integrin ITGAV:ITGB3 acts aP05556s a receptor for human parechovirus 1 . Integrin ITGAV:ITGB3 acts as a receptor for west nile virus . In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions .

Protein tissue specificity

Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Involvement in disease

Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the integrin beta chain family. / Contains 1 VWFA domain.

Protein post-translational modifications

Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.

Protein cellular localization

Cell membrane / Single-pass type I membrane protein / Cell projection > lamellipodium membrane / Cell junction > focal adhesion

Research area

All research areas>Cell Adhesion Proteins>Integrin β 3
(View all antibody categories related to Cell Adhesion Proteins)

Note

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Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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Immunohistochemical analysis of paraffin embedded Human breast cancer tissue

1: Integrin beta3 Polyclonal Antibody was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Human liver tissue

1: Integrin beta3 Polyclonal Antibody was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Human liver cancer tissue

1: Integrin beta3 Polyclonal Antibody was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Human lung cancer tissue

1: Integrin beta3 Polyclonal Antibody was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Human kidney tissue

1: Integrin beta3 Polyclonal Antibody was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.
 

Immunohistochemical analysis of paraffin embedded Human kidney cancer tissue

1: Integrin beta3 Polyclonal Antibody was diluted at 1:200 (4 degree Celsius,overnight).
2: Sodium citrate pH 6.0 was used for antibody retrieval (>98 degree Celsius,20min).
3: Secondary antibody was diluted at 1:200 (room temperature, 30min). Negative control was used by secondary antibody only.


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