Rabbit polyclonal IPO5 antibody (A1984)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IPO5 antibody (A1984)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal IPO5 antibody.

Alternative names:

Check alternative names for the antibody

Expand

IMB3 antibody, Pse1 antibody, imp5 antibody, KPNB3 antibody, RANBP5 antibody
DKFZp686O1576 antibody|FLJ43041 antibody|IMB3 antibody|Imp5 antibody|Importin 5 antibody|Importin beta 3 subunit antibody|Importin subunit beta 3 antibody|Importin subunit beta-3 antibody|Importin-5 antibody|IPO 5 antibody|IPO5 antibody|IPO5_HUMAN antibody|Karyopherin beta 3 antibody|Karyopherin beta-3 antibody|KPNB3 antibody|MGC2068 antibody|Pse1 antibody|Ran binding protein 5 antibody|Ran GTP binding protein 5 antibody|Ran-binding protein 5 antibody|RanBP 5 antibody|RanBP5 antibody|Anti-Karyopherin beta 3 antibody (ab187175)

SCBT cat No: sc-84578|sc-514122|sc-55527|sc-17801|sc-11369|sc-17802|

Name

Rabbit polyclonal IPO5 antibody

Catalogue No.

A1984

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human IPO5

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 123kDa/Observed: Refer to Figures

Formulation

IPO5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IPO5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IMB3 antibody, Pse1 antibody, imp5 antibody, KPNB3 antibody, RANBP5 antibody

Database links

Human UniProt/Swiss-Prot:O00410

Protein names

IMB3, Pse1, imp5, KPNB3, RANBP5

Protein function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

Protein sequence and domain

Belongs to the importin beta family. Importin beta-3 subfamily.; Contains 24 HEAT repeats.; Contains 1 importin N-terminal domain.

Protein cellular localization

Cytoplasm. Nucleus. Nucleus, nucleolus. Note: Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.

Background

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

Research area

All research areas>Transport and Trafficking>karyopherin
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus can customize IPO5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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