Rabbit polyclonal IRAK4 antibody (A6208)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IRAK4 antibody (A6208)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal IRAK4 antibody.

Alternative names:

Check alternative names for the antibody

Expand

IPD1 antibody, REN64 antibody, IRAK-4 antibody, NY-REN-64 antibody
IL-1 receptor-associated kinase 4 antibody|Interleukin 1 receptor associated kinase 4 mutant form 1 antibody|Interleukin-1 receptor-associated kinase 4 antibody|Interleukin1 receptor associated kinase 4 antibody|IPD1 antibody|IRAK 4 antibody|IRAK-4 antibody|IRAK4 antibody|IRAK4 mutated form 1 antibody|IRAK4_HUMAN antibody|LOC 51135 antibody|NY REN 64 antibody|NY REN 64 antigen antibody|NY-REN-64 antibody|REN64 antibody|Renal carcinoma antigen NY-REN-64 antibody|Anti-IRAK4 antibody [2H9] (ab119942)

SCBT cat No: sc-134368|sc-374349|sc-99154|sc-34469|sc-34470|

Name

Rabbit polyclonal IRAK4 antibody

Catalogue No.

A6208

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human IRAK4

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 51kDa/Observed: Refer to Figures

Formulation

IRAK4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IRAK4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IPD1 antibody, REN64 antibody, IRAK-4 antibody, NY-REN-64 antibody

Database links

Human UniProt/Swiss-Prot:Q9NWZ3

Protein names

IPD1, REN64, IRAK-4, NY-REN-64

Protein function

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways . Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

Protein sequence and domain

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.; Contains 1 death domain.; Contains 1 protein kinase domain.

Protein post-translational modifications

Phosphorylated.

Protein cellular localization

Cytoplasm .

Background

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Kinases and Phosphatases>IRAK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize IRAK4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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