Rabbit polyclonal IRF8 antibody (A5798)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal IRF8 antibody (A5798)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

ICSBP antibody, IRF-8 antibody, ICSBP1 antibody, H-ICSBP antibody
H ICSBP antibody|H-ICSBP antibody|HGNC:5358 antibody|HICSBP antibody|ICSBP 1 antibody|ICSBP antibody|ICSBP1 antibody|Interferon consensus sequence binding protein 1 antibody|Interferon consensus sequence binding protein antibody|Interferon consensus sequence-binding protein antibody|Interferon regulatory factor 8 antibody|IRF 8 antibody|IRF-8 antibody|Irf8 antibody|IRF8_HUMAN antibody|MYLS antibody|Anti-IRF8 antibody (ab28696)

SCBT cat No: sc-393676|sc-6058|sc-365042|sc-398237|sc-365041|sc-393955|sc-13043|

Name

Rabbit polyclonal IRF8 antibody

Catalogue No.

A5798

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human IRF8

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 48kDa/Observed: Refer to Figures

Formulation

IRF8 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

IRF8 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ICSBP antibody, IRF-8 antibody, ICSBP1 antibody, H-ICSBP antibody

Database links

Human UniProt/Swiss-Prot:Q02556

Protein names

ICSBP, IRF-8, ICSBP1, H-ICSBP

Protein function

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5′-TGAnTCA/GAAA-3′), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).

Protein tissue specificity

Predominantly expressed in lymphoid tissues.

Protein sequence and domain

Belongs to the IRF family.; Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

Protein post-translational modifications

Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes (By similarity).

Protein cellular localization

Nucleus .

Background

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.

Note

AntibodyPlus can customize IRF8 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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