Rabbit polyclonal ITGA6 antibody (A3236)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal ITGA6 antibody (A3236)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ITGA6 antibody.

Alternative names:

Check alternative names for the antibody

Expand

CD49f antibody, VLA-6 antibody, ITGA6B antibody
Alpha6p antibody|CD49 antigen-like family member F antibody|CD49f antibody|Integrin alpha6B antibody|Integrin, alpha 6 antibody|ITA6_HUMAN antibody|ITGA6 antibody|ITGA6B antibody|Processed integrin alpha-6 antibody|VLA 6 antibody|VLA-6 antibody|Anti-Integrin alpha 6 antibody [MP 4F10] (ab20142)

SCBT cat No: sc-71426|sc-71427|sc-71423|sc-59842|sc-53356|sc-47772|sc-13542|sc-6596|sc-374057|sc-19622|sc-10730|sc-6597|sc-80554|sc-81807|sc-27710|

Name

Rabbit polyclonal ITGA6 antibody

Catalogue No.

A3236

Reactivity

Human

Immunogen

Recombinant protein of human ITGA6

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 125kDa/Observed: Refer to Figures

Formulation

ITGA6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ITGA6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD49f antibody, VLA-6 antibody, ITGA6B antibody

Database links

Human UniProt/Swiss-Prot:P23229

Protein names

CD49f, VLA-6, ITGA6B

Protein function

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling . ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling .

Protein tissue specificity

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).

Protein sequence and domain

Belongs to the integrin alpha chain family.; Contains 7 FG-GAP repeats.

Protein post-translational modifications

Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on ‘Ser-1103’ of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.; In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.; Palmitoylation by DHHC3 enhances stability and cell surface expression.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Cell membrane ; Lipid-anchor .

Background

Integrins are alpha/beta heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 alpha and 8 beta subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2).Integrin alpha6 is a 120 kDa protein with two splice variants, integrin alpha6, 6A and 6B (3), which function as receptors for laminins on the basal membrane to mediate cellular adhesion events (4-6). alpha6 integrins have been shown to play an important role in hematopoietic stem and progenitor cell homing to the bone marrow.

Research area

All research areas>Cell Adhesion Proteins>Integrin
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize ITGA6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!