Rabbit polyclonal ITGAV antibody (A2091)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ITGAV antibody (A2091)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CD51 antibody, MSK8 antibody, VNRA antibody, VTNR antibody
Antigen identified by monoclonal antibody L230 antibody|CD51 antibody|CD51 antigen antibody|CD61 antibody|CD61 antigen antibody|DKFZp686A08142 antibody|GP3A antibody|GPIIIa antibody|Integrin alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) antibody|Integrin alpha v antibody|Integrin beta 3 (platelet glycoprotein IIIa, antigen CD61) antibody|Integrin beta 3 antibody|Integrin beta chain beta 3 antibody|ITGAV antibody|ITGB3 antibody|MSK8 antibody|Platelet glycoprotein IIIa antibody|Platelet membrane glycoprotein IIIa antibody|Vitronectin receptor subunit alpha antibody|VNRA antibody|Anti-CD51 + CD61 antibody [BV3] (ab7166)

SCBT cat No: sc-7312|sc-52684|sc-81632|sc-13588|sc-59970|sc-59971|sc-71453|sc-71454|sc-71455|sc-1185|sc-71456|sc-46676|sc-19989|sc-19618|sc-6619|sc-398708|sc-26692|sc-398725|

Name

Rabbit polyclonal ITGAV antibody

Catalogue No.

A2091

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human ITGAV

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 115kDa/Observed: Refer to Figures

Formulation

ITGAV antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ITGAV antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD51 antibody, MSK8 antibody, VNRA antibody, VTNR antibody

Database links

Human UniProt/Swiss-Prot:P06756

Protein names

CD51, MSK8, VNRA, VTNR

Protein function

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling . ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling . ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling . ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling . ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 . ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 .; (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C . Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for coxsackievirus A9 and B1 . Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 . Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1 . Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1 . Integrin ITGAV:ITGB3 acts as a receptor for West nile virus . In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions .

Protein sequence and domain

Belongs to the integrin alpha chain family.; Contains 7 FG-GAP repeats.

Protein cellular localization

Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion .

Background

Integrins are alpha/beta heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 alpha and 8 beta subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1,2).Several alphaV subfamily members, including alphaVbeta3, alphaVbeta5, alphaVbeta1, are highly expressed in active endothelial cells and cancer cells (3-6) where they play a critical role in angiogenesis and tumor metastasis (7-9). Therefore, interest has focused on alphaV integrin as a key therapeutic target in the treatment of cancer (10-12).

Research area

All research areas>Cell Adhesion Proteins>Integrin
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize ITGAV antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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