Rabbit polyclonal ITGB7 antibody (A5873)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ITGB7 antibody (A5873)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ITGB7 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ITGB7 antibody, Integrin beta 7 antibody, integrin antibody, beta 7 antibody
Gut homing receptor beta subunit antibody|Integrin beta 7 subunit antibody|Integrin beta-7 antibody|Integrin beta-P antibody|Integrin, beta 7 antibody|ITB7 antibody|ITB7_HUMAN antibody|Itgb7 antibody|Ly69 antibody|M290 IEL antigen antibody|Anti-Integrin beta 7 antibody (Biotin) [FIB504]

SCBT cat No: sc-6637|sc-23919|

Name

Rabbit polyclonal ITGB7 antibody

Catalogue No.

A5873

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human ITGB7

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 87kDa/Observed: Refer to Figures

Formulation

ITGB7 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ITGB7 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ITGB7 antibody, Integrin beta 7 antibody, integrin antibody, beta 7 antibody

Database links

Human UniProt/Swiss-Prot:P26010

Protein names

ITGB7, Integrin beta 7, integrin, beta 7

Protein function

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Protein tissue specificity

Expressed in a variety of leukocyte lines.

Protein sequence and domain

Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.Belongs to the integrin beta chain family.; Contains 1 VWFA domain.

Protein cellular localization

Membrane; Single-pass type I membrane protein.

Background

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer’s patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Research area

All research areas>Cell Adhesion Proteins>Integrin
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize ITGB7 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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