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Rabbit polyclonal ITPK1 antibody (A8312)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal ITPK1 antibody.
Check alternative names for the antibodyExpand
3 antibody|4 antibody|5)-tetrakisphosphate 3-phosphatase antibody|5)P(4) 3-phosphatase antibody|DKFZp564L2016 antibody|HIPER1 antibody|Inositol (1 antibody|inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase antibody|Ins(1 antibody|ins(1,3,4,5)P(4) 3-phosphatase antibody|MINP1_HUMAN antibody|Minpp1 antibody|MINPP2 antibody|MIPP antibody|Multiple inositol polyphosphate histidine phosphatase, 1 antibody|Multiple inositol polyphosphate phosphatase 1 antibody|multiple inositol polyphosphate phosphatase 2 antibody|Anti-ITPK1 antibody [EPR10631] (ab175222)
SCBT cat No:
Rabbit polyclonal ITPK1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human ITPK1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 46kDa/Observed: Refer to figures
ITPK1 antibody was tube-contained.
ITPK1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
|Protein tissue specificity|| |
Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen.
|Protein sequence and domain|| |
Belongs to the ITPK1 family.; Contains 1 ATP-grasp domain.
|Protein post-translational modifications|| |
Acetylation by EP300 and CREBBP destabilizes ITPK1, and down-regulates enzymatic activity. Deacetylated by SIRT1.
AntibodyPlus can customize ITPK1 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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