Rabbit polyclonal ITPK1 antibody (A8312)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ITPK1 antibody (A8312)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ITPK1 antibody.

Alternative names:

Check alternative names for the antibody

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ITRPK1 antibody
3 antibody|4 antibody|5)-tetrakisphosphate 3-phosphatase antibody|5)P(4) 3-phosphatase antibody|DKFZp564L2016 antibody|HIPER1 antibody|Inositol (1 antibody|inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase antibody|Ins(1 antibody|ins(1,3,4,5)P(4) 3-phosphatase antibody|MINP1_HUMAN antibody|Minpp1 antibody|MINPP2 antibody|MIPP antibody|Multiple inositol polyphosphate histidine phosphatase, 1 antibody|Multiple inositol polyphosphate phosphatase 1 antibody|multiple inositol polyphosphate phosphatase 2 antibody|Anti-ITPK1 antibody [EPR10631] (ab175222)

SCBT cat No:

Name

Rabbit polyclonal ITPK1 antibody

Catalogue No.

A8312

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ITPK1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 46kDa/Observed: Refer to figures

Formulation

ITPK1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ITPK1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ITRPK1 antibody

Database links

Human UniProt/Swiss-Prot:Q13572

Protein names

ITRPK1

Protein function

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

Protein tissue specificity

Expressed in brain > heart > skeletal muscle = kidney = pancreas = liver = placenta > lung. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal cord, occipital lobe, frontal lobe, temporal lobe and putamen.

Protein sequence and domain

Belongs to the ITPK1 family.; Contains 1 ATP-grasp domain.

Protein post-translational modifications

Acetylation by EP300 and CREBBP destabilizes ITPK1, and down-regulates enzymatic activity. Deacetylated by SIRT1.

Note

AntibodyPlus can customize ITPK1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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