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Rabbit polyclonal JAK2 antibody (A7694)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal JAK2 antibody.
Check alternative names for the antibodyExpand
JTK10 antibody, THCYT3 antibody
JAK 2 antibody|JAK-2 antibody|JAK2 antibody|JAK2_HUMAN antibody|Janus Activating Kinase 2 antibody|Janus kinase 2 (a protein tyrosine kinase) antibody|Janus kinase 2 antibody|JTK 10 antibody|JTK10 antibody|kinase Jak2 antibody|OTTHUMP00000043260 antibody|THCYT3 antibody|Tyrosine protein kinase JAK2 antibody|Tyrosine-protein kinase JAK2 antibody|Phospho anti-JAK2 (Y1007 + Y1008) antibody [E132] (ab32101)
SCBT cat No: sc-390539|sc-34479|sc-294|sc-278|sc-7229|sc-34480|sc-71461|sc-56921|sc-6932|sc-34481|
Rabbit polyclonal JAK2 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A synthetic peptide of human JAK2
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 131kDa/Observed: Refer to Figures
JAK2 antibody was tube-contained.
JAK2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
JTK10 antibody, THCYT3 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins . Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins . Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation . Plays a role in cell cycle by phosphorylating CDKN1B . Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of ‘Tyr-41’ of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin .
|Protein tissue specificity|| |
Ubiquitously expressed throughout most tissues.
|Protein sequence and domain|| |
Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1 (By similarity).Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.; Contains 1 FERM domain.; Contains 2 protein kinase domains.; Contains 1 SH2 domain.
|Protein post-translational modifications|| |
Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813 (By similarity). Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity (By similarity). Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity (By similarity). Also phosphorylated by TEC (By similarity). Phosphorylated on tyrosine residues in response to interferon gamma signaling .
|Protein cellular localization|| |
Endomembrane system ; Peripheral membrane protein . Cytoplasm . Nucleus .
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
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|Product type|| |
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