Rabbit polyclonal JAK2 antibody (A7694)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal JAK2 antibody (A7694)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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JTK10 antibody, THCYT3 antibody
JAK 2 antibody|JAK-2 antibody|JAK2 antibody|JAK2_HUMAN antibody|Janus Activating Kinase 2 antibody|Janus kinase 2 (a protein tyrosine kinase) antibody|Janus kinase 2 antibody|JTK 10 antibody|JTK10 antibody|kinase Jak2 antibody|OTTHUMP00000043260 antibody|THCYT3 antibody|Tyrosine protein kinase JAK2 antibody|Tyrosine-protein kinase JAK2 antibody|Phospho anti-JAK2 (Y1007 + Y1008) antibody [E132] (ab32101)

SCBT cat No: sc-390539|sc-34479|sc-294|sc-278|sc-7229|sc-34480|sc-71461|sc-56921|sc-6932|sc-34481|

Name

Rabbit polyclonal JAK2 antibody

Catalogue No.

A7694

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human JAK2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 131kDa/Observed: Refer to Figures

Formulation

JAK2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

JAK2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

JTK10 antibody, THCYT3 antibody

Database links

Human UniProt/Swiss-Prot:O60674

Protein names

JTK10, THCYT3

Protein function

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins . Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins . Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation . Plays a role in cell cycle by phosphorylating CDKN1B . Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of ‘Tyr-41’ of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin .

Protein tissue specificity

Ubiquitously expressed throughout most tissues.

Protein sequence and domain

Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1 (By similarity).Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.; Contains 1 FERM domain.; Contains 2 protein kinase domains.; Contains 1 SH2 domain.

Protein post-translational modifications

Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813 (By similarity). Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity (By similarity). Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity (By similarity). Also phosphorylated by TEC (By similarity). Phosphorylated on tyrosine residues in response to interferon gamma signaling .

Protein cellular localization

Endomembrane system ; Peripheral membrane protein . Cytoplasm . Nucleus .

Background

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.

Research area

All research areas>Kinases and Phosphatases>JAK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize JAK2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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