Rabbit polyclonal JARID2 antibody (A9823)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal JARID2 antibody (A9823)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal JARID2 antibody.

Alternative names:

Check alternative names for the antibody

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JARD2 antibody|JARD2_HUMAN antibody|JARID2 antibody|JMJ antibody|Jumonji AT rich interactive domain 2 antibody|Jumonji homolog antibody|Jumonji like protein antibody|Jumonji protein antibody|Jumonji/ARID domain containing protein 2 antibody|Jumonji/ARID domain-containing protein 2 antibody|Protein Jumonji antibody|Anti-Jarid2 antibody (ab48137)

SCBT cat No:

Name

Rabbit polyclonal JARID2 antibody

Catalogue No.

A9823

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human JARID2

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 139kDa/Observed: Refer to figures

Formulation

JARID2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

JARID2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q92833

Protein function

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of ‘Lys-27’ of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of ‘Lys-9’ of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

Protein tissue specificity

During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.

Protein sequence and domain

The ARID domain is required to target the PRC2 complex to its target genes.; The GSGFP motif is required for the interaction with SUZ12.Contains 1 ARID domain.; Contains 1 JmjC domain.; Contains 1 JmjN domain.

Protein cellular localization

Nucleus . Note: Colocalizes with the PRC2 complex on chromatin.

Note

AntibodyPlus can customize JARID2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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