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Rabbit polyclonal JARID2 antibody (A9823)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal JARID2 antibody.
Check alternative names for the antibodyExpand
JARD2 antibody|JARD2_HUMAN antibody|JARID2 antibody|JMJ antibody|Jumonji AT rich interactive domain 2 antibody|Jumonji homolog antibody|Jumonji like protein antibody|Jumonji protein antibody|Jumonji/ARID domain containing protein 2 antibody|Jumonji/ARID domain-containing protein 2 antibody|Protein Jumonji antibody|Anti-Jarid2 antibody (ab48137)
SCBT cat No:
Rabbit polyclonal JARID2 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human JARID2
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 139kDa/Observed: Refer to figures
JARID2 antibody was tube-contained.
JARID2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of ‘Lys-27’ of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of ‘Lys-9’ of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
|Protein tissue specificity|| |
During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.
|Protein sequence and domain|| |
The ARID domain is required to target the PRC2 complex to its target genes.; The GSGFP motif is required for the interaction with SUZ12.Contains 1 ARID domain.; Contains 1 JmjC domain.; Contains 1 JmjN domain.
|Protein cellular localization|| |
Nucleus . Note: Colocalizes with the PRC2 complex on chromatin.
AntibodyPlus can customize JARID2 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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