Rabbit polyclonal KAT7 antibody (A5823)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KAT7 antibody (A5823)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KAT7 antibody.

Alternative names:

Check alternative names for the antibody

Expand

HBO1 antibody, HBOA antibody, MYST2 antibody, ZC2HC7 antibody
Hbo 1 antibody|HBO1 antibody|HBOa antibody|Histone acetyltransferase binding to hORC1 antibody|Histone acetyltransferase binding to ORC1 antibody|Histone acetyltransferase KAT7 antibody|Histone acetyltransferase MYST2 antibody|K(lysine) acetyltransferase 7 antibody|KAT 7 antibody|KAT7 antibody|Lysine acetyltransferase 7 antibody|MOZ antibody|MOZ YBF2/SAS3 SAS2 and TIP60 protein antibody|MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 antibody|MYST 2 antibody|MYST histone acetyltransferase 2 antibody|MYST protein 2 antibody|MYST-2 antibody|MYST2 antibody|MYST2_HUMAN antibody|SAS 2 antibody|SAS2 and TIP60 protein 2 antibody|TIP60 protein 2 antibody|YBF2/SAS3 antibody|ZC2HC7 antibody|Anti-KAT7 / Hbo1 / MYST2 antibody (ab70183)

SCBT cat No: sc-398346|sc-25379|sc-13283|sc-13284|

Name

Rabbit polyclonal KAT7 antibody

Catalogue No.

A5823

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human KAT7

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 71kDa/Observed: Refer to Figures

Formulation

KAT7 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KAT7 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HBO1 antibody, HBOA antibody, MYST2 antibody, ZC2HC7 antibody

Database links

Human UniProt/Swiss-Prot:O95251

Protein names

HBO1, HBOA, MYST2, ZC2HC7

Protein function

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.

Protein tissue specificity

Ubiquitously expressed, with highest levels in testis.

Protein sequence and domain

The C2HC MYST-type zinc finger is required for interaction with MCM2 and ORC1L.; The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.Belongs to the MYST (SAS/MOZ) family.; Contains 1 C2HC MYST-type zinc finger.; Contains 1 CCHHC-type zinc finger.; Contains 1 MYST-type HAT (histone acetyltransferase) domain.

Protein post-translational modifications

Phosphorylation at Ser-57 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior Phosphorylation at Thr-85 and Thr-88 by CDK1.; Autoacetylation at Lys-432 is required for proper function.

Protein cellular localization

Nucleus, nucleoplasm .

Background

MYST2, also named as HBO1, HBOa MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, belongs to the MYST (SAS/MOZ) family. It specifically represses AR mediated transcription. MYST2 is a candidate oncogene. It enhances the anchorage-independent growth of breast cancer cells.(PMID:19372580) MYST2 is a histone acetyltransferase (HAT) which could exert oncogenic function in breast cancer. It is an important downstream molecule of ERa, and ERK1/2 signaling pathway may involved in the expression of HBO1 increased by E2.

Research area

All research areas>Transcription Regulators>HBO1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize KAT7 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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