Rabbit polyclonal KCND3 antibody (A6927)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal KCND3 antibody (A6927)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KCND3 antibody.

Alternative names:

Check alternative names for the antibody

Expand

KV4.3 antibody, SCA19 antibody, SCA22 antibody, KCND3L antibody, KCND3S antibody, KSHIVB antibody
KCND 3 antibody|Potassium voltage gated channel subfamily D member 3 antibody|Voltage gated K+ channel antibody|Voltage gated potassium channel Kv4.3 antibody|Voltage gated potassium channel subunit Kv4.3 antibody|Voltage-gated potassium channel subunit Kv4.3 antibody|Anti-Kv4.3 antibody [S75-41] (ab99045)

SCBT cat No: sc-11686|

Name

Rabbit polyclonal KCND3 antibody

Catalogue No.

A6927

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human KCND3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 73kDa/Observed: Refer to figures

Formulation

KCND3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KCND3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

KV4.3 antibody, SCA19 antibody, SCA22 antibody, KCND3L antibody, KCND3S antibody, KSHIVB antibody

Database links

Human UniProt/Swiss-Prot:Q9UK17

Protein names

KV4.3, SCA19, SCA22, KCND3L, KCND3S, KSHIVB

Protein function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

Protein tissue specificity

Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas.

Protein sequence and domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily.

Protein post-translational modifications

Regulated through phosphorylation at Ser-569 by CaMK2D.

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Cell membrane, sarcolemma ; Multi-pass membrane protein . Cell projection, dendrite . Note: Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression.

Background

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes – shaker, shaw, shab, and shal – have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.

Research area

All research areas>Channel Proteins>KV
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize KCND3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!