Rabbit polyclonal KCNE1 antibody (A1176)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KCNE1 antibody (A1176)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

KCNE1 antibody,FLJ18426 antibody,FLJ38123 antibody,FLJ94103 antibody,ISK antibody,JLNS antibody,JLNS2 antibody,LQT2/5 antibody,LQT5 antibody,MGC33114 antibody,MinK antibody
Delayed rectifier potassium channel subunit IsK antibody|Potassium voltage gated channel subfamily E member 1 antibody|Potassium voltage-gated channel subfamily E member 1 antibody|Anti-KCNE1 antibody (ab135001)

SCBT cat No: sc-367302|sc-16796|

Name

Rabbit polyclonal KCNE1 antibody

Catalogue No.

A1176

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human KCNE1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 15kDa/Observed: Refer to Figures

Formulation

KCNE1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KCNE1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

KCNE1 antibody,FLJ18426 antibody,FLJ38123 antibody,FLJ94103 antibody,ISK antibody,JLNS antibody,JLNS2 antibody,LQT2/5 antibody,LQT5 antibody,MGC33114 antibody,MinK antibody

Database links

Human UniProt/Swiss-Prot:P15382

Protein names

KCNE1,FLJ18426,FLJ38123,FLJ94103,ISK,JLNS,JLNS2,LQT2/5,LQT5,MGC33114,MinK

Protein function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 . Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).

Protein tissue specificity

Expressed in lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Expressed in the heart . Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells.

Protein sequence and domain

Belongs to the potassium channel KCNE family.

Protein post-translational modifications

Phosphorylation inhibits the potassium current.; N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Apical cell membrane . Membrane raft . Note: Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KNCQ1 .

Background

Voltage-gated potassium channels play a variety of important roles in human health and disease (1,2). KCNE1, also known as MinK, belongs to a family of small transmembrane proteins (KCNE1, 2, 3, 4, and KCNE1L) that modulate the activity of several voltage-gated K+ channels (3-5). KCNE1 functions as the modulatory beta-subunit of the pore-forming alpha-subunit KCNQ1, and alters several biophysical properties of KCNQ1 channels (6,7). Research studies have shown that several inherited mutations in KCNE1 result in long QT syndrome (8-10) and deafness (11).

Research area

All research areas>Channel Proteins>KCN
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize KCNE1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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