Rabbit polyclonal KCNH1 antibody (A6636)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KCNH1 antibody (A6636)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KCNH1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

EAG antibody, EAG1 antibody, h-eag antibody, Kv10.1 antibody
EAG antibody|Potassium voltage-gated channel subfamily H member 1 antibody|Voltage gated potassium channel subunit Kv10.1 antibody|Voltage-gated potassium channel subunit Kv10.1 antibody|Anti-KCNH1 antibody (ab194350)

SCBT cat No: sc-398585|sc-161766|

Name

Rabbit polyclonal KCNH1 antibody

Catalogue No.

A6636

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human KCNH1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 111kDa/Observed: Refer to figures

Formulation

KCNH1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KCNH1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EAG antibody, EAG1 antibody, h-eag antibody, Kv10.1 antibody

Database links

Human UniProt/Swiss-Prot:O95259

Protein names

EAG, EAG1, h-eag, Kv10.1

Protein function

Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel . Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts . Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) .

Protein tissue specificity

Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.

Protein sequence and domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.; The C-terminal region interacts with the cyclic nucleotide-binding domain and contributes to regulate channel gating.; The PAS domain interacts with the cyclic nucleotide-binding domain and contributes to regulate channel gating.; The cyclic nucleotide-binding domain lacks residues that are essential for nucleotide-binding and cannot bind cyclic nucleotides. Instead, residues from the C-terminal domain (the so-called intrinsic ligand) bind in the cavity that would be expected to bind cyclic nucleotides. Interaction with the C-terminal region hinders interaction with CALM and reduces the affinity for CALM.Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily.; Contains 1 cyclic nucleotide-binding domain.; Contains 1 PAC (PAS-associated C-terminal) domain.; Contains 1 PAS (PER-ARNT-SIM) domain.

Protein post-translational modifications

Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6 .

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Nucleus inner membrane ; Multi-pass membrane protein . Early endosome membrane . Note: Perinuclear KCNH1 is located to NPC-free islands.

Background

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

Note

AntibodyPlus can customize KCNH1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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