Rabbit polyclonal KCNH2 antibody (A2968)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KCNH2 antibody (A2968)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KCNH2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ERG1 antibody, HERG antibody, LQT2 antibody, SQT1 antibody, HERG1 antibody, Kv11.1 antibody
eag homolog antibody|H ERG antibody|Potassium voltage-gated channel subfamily H member 2 antibody|SQT1 antibody|Voltage gated potassium channel, subfamily H, member 2 antibody|Voltage-gated potassium channel subunit Kv11.1 antibody|Anti-KCNH2 antibody (ab136467)

SCBT cat No: sc-15968|sc-377388|sc-20130|sc-15966|

Name

Rabbit polyclonal KCNH2 antibody

Catalogue No.

A2968

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human KCNH2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 90kDa/Observed: Refer to Figures

Formulation

KCNH2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KCNH2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ERG1 antibody, HERG antibody, LQT2 antibody, SQT1 antibody, HERG1 antibody, Kv11.1 antibody

Database links

Human UniProt/Swiss-Prot:Q12809

Protein names

ERG1, HERG, LQT2, SQT1, HERG1, Kv11.1

Protein function

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.

Protein tissue specificity

Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells.

Protein sequence and domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.; Contains 1 cyclic nucleotide-binding domain.; Contains 1 PAC (PAS-associated C-terminal) domain.; Contains 1 PAS (PER-ARNT-SIM) domain.

Protein post-translational modifications

Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.

Protein cellular localization

Cell membrane ; Multi-pass membrane protein .

Background

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.

Research area

All research areas>Channel Proteins>HERG
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize KCNH2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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