Rabbit Polyclonal KCNMB2 antibody (A10277)

$99.00$259.00

Reactivity: Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal KCNMB2 antibody (A10277)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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2700049B16Rik antibody|3110031N04Rik antibody|BK channel subunit beta 2 antibody|BK channel subunit beta-2 antibody|BKbeta2 antibody|Calcium activated potassium channel subfamily M subunit beta 2 antibody|Calcium activated potassium channel subunit beta 2 antibody|Calcium-activated potassium channel antibody|Calcium-activated potassium channel subunit beta-2 antibody|Charybdotoxin receptor subunit beta 2 antibody|Charybdotoxin receptor subunit beta-2 antibody|Hbeta2 antibody|Hbeta3 antibody|K(VCA)beta-2 antibody|K(VCA)beta2 antibody|KCMB2_HUMAN antibody|KCNMB 2 antibody|Kcnmb2 antibody|Large conductance Ca2+ activated K+ channel beta2 subunit antibody|Large conductance calcium activated potassium channel beta 2 subunit antibody|Maxi K channel subunit beta 2 antibody|Maxi K channel subunit beta-2 antibody|MaxiK channel beta 2 subunit antibody|MGC22431 antibody|MGC57945 antibody|Potassium large conductance calcium activated channel subfamily M beta member 2 antibody|Slo-beta-2 antibody|Slobeta2 antibody|subfamily M subunit beta-2 antibody|Anti-KCNMB2 antibody [S53-32] (ab94589)

SCBT cat No:

Name

Rabbit Polyclonal KCNMB2 antibody

Catalogue No.

A10277

Reactivity

Mouse, Rat

Immunogen

Recombinant protein of human KCNMB2

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

27kDa

Formulation

KCNMB2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Protein function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.

Protein tissue specificity

Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.

Protein sequence and domain

Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily. The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus.

Protein post-translational modifications

N-glycosylated.

Protein cellular localization

Membrane; Multi-pass membrane protein.

Background

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described.

Note

AntibodyPlus can customize KCNMB2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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