Rabbit polyclonal KCNQ1 antibody (A2174)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KCNQ1 antibody (A2174)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KCNQ1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

KCNQ1 antibody, ATFB1 antibody, ATFB3 antibody, JLNS1 antibody, KCNA8 antibody, KCNA9 antibody, KVLQT1 antibody, Kv1.9 antibody, Kv7.1 antibody, LQT antibody, LQT1 antibody, RWS antibody, SQT2 antibody, WRS antibody
ATFB1 antibody|ATFB3 antibody|FLJ26167 antibody|IKs producing slow voltage-gated potassium channel subunit alpha antibody|IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 antibody|Jervell and Lange-Nielsen syndrome 1 antibody|JLNS1 antibody|KCNA8 antibody|KCNA9 antibody|KCNQ1 antibody|KCNQ1_HUMAN antibody|kidney and cardiac voltage dependend K+ channel antibody|KQT-like 1 antibody|Kv1.9 antibody|Kv7.1 antibody|KVLQT1 antibody|long (electrocardiographic) QT syndrome, Ward-Romano syndrome 1 antibody|LQT antibody|LQT1 antibody|Potassium channel, voltage-gated, shaker-relatd subfamily, member 9 antibody|Potassium voltage-gated channel subfamily KQT member 1 antibody|potassium voltage-gated channel, KQT-like subfamily, member 1 antibody|RWS antibody|slow delayed rectifier channel subunit antibody|SQT2 antibody|Voltage-gated potassium channel subunit Kv7.1 antibody|WRS antibody|Anti-KCNQ1 antibody [S37A-10] (ab84819)

SCBT cat No: sc-10646|sc-365764|sc-365186|sc-20816|sc-10645|

Name

Rabbit polyclonal KCNQ1 antibody

Catalogue No.

A2174

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human KCNQ1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 61kDa/Observed: Refer to Figures

Formulation

KCNQ1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KCNQ1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

KCNQ1 antibody, ATFB1 antibody, ATFB3 antibody, JLNS1 antibody, KCNA8 antibody, KCNA9 antibody, KVLQT1 antibody, Kv1.9 antibody, Kv7.1 antibody, LQT antibody, LQT1 antibody, RWS antibody, SQT2 antibody, WRS antibody

Database links

Human UniProt/Swiss-Prot:P51787

Protein names

KCNQ1, ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS

Protein function

Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity) . Associates with KCNE beta subunits that modulates current kinetics (By similarity) . Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) . Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) . Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current . When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions . This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current . When associated with KCNE4, inhibits voltage-gated potassium channel activity . When associated with KCNE5, this complex only conducts current upon strong and continued depolarization . Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity . Binds with phosphatidylinositol 4,5-bisphosphate .; Isoform 2: Non-functional alone but modulatory when coexpressed with the full-length isoform 1.

Protein tissue specificity

Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries.

Protein sequence and domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.; The coiled-coil domain mediates tetramerization.; The segment S6 is involved in the inhibition of voltage-gated potassium channel activity by KCNE4.; The C-terminal assembly domain promotes self-interactiona; allows functional channel.Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.

Protein post-translational modifications

Phosphorylation at Ser-27 by PKA; increases delayed rectifier potassium channel activity of the KCNQ1-KCNE1 complex through a macromolecular complex that includes PKA, PP1, and the targeting protein AKAP9.; Ubiquitinated by NEDD4L; promotes internalization . The ubiquitinylated form is internalized through a clathrin-mediated endocytosis by interacting with AP2M1 and is recycled back to the cell membrane via RAB4A and RAB11A .; Deubiquitinated by USP2; counteracts the NEDD4L-specific down-regulation of I(Ks) and restores the membrane localization.

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane . Early endosome . Membrane raft . Endoplasmic reticulum . Basolateral cell membrane . Note: Colocalized with KCNE3 at the plasma membrane . Upon 17beta-oestradiol treatment, colocalizes with RAB5A at early endosome . Heterotetramer with KCNQ5 is highly retained at the endoplasmic reticulum and is localized outside of lipid raft microdomains . During the early stages of epithelial cell polarization induced by the calcium switch it removed from plasma membrane to the endoplasmic reticulum where it retained and it is redistributed to the basolateral cell surface in a PI3K-dependent manner at a later stage .

Background

KCNQ1 is a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3.

Note

AntibodyPlus can customize KCNQ1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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